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Protein

Argininosuccinate synthase

Gene

argG

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88CitrullineUniRule annotation1
Binding sitei118ATP; via amide nitrogenUniRule annotation1
Binding sitei120AspartateUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei124CitrullineUniRule annotation1
Binding sitei125AspartateUniRule annotation1
Binding sitei128CitrullineUniRule annotation1
Binding sitei177CitrullineUniRule annotation1
Binding sitei186CitrullineUniRule annotation1
Binding sitei262CitrullineUniRule annotation1
Binding sitei274CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1151-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:CT1114
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001485831 – 401Argininosuccinate synthaseAdd BLAST401

Proteomic databases

PRIDEiQ8KDE0

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT1114

Structurei

3D structure databases

ProteinModelPortaliQ8KDE0
SMRiQ8KDE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KDE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEKIAVAY SGGLDTSVMI KWLKDKYEGA EIVAVTGNLG QKMEVDNLEQ
60 70 80 90 100
KAIATGAKSF HFVDLRKTFV EEYIWKALKA GALYEDVYPL ATALGRPLLA
110 120 130 140 150
KALVDVALAE GCTMLTHGCT GKGNDQVRFE VAFAALAPHM KVVAPLREWE
160 170 180 190 200
FTSREQEIAY AMEHNIPVSA TKKNPYSIDE NIWGISIECG VLEDPMVAPP
210 220 230 240 250
ADAYQITTAP ELAPDEPTVV DIEFAQGVPV ALDGQQMEGL DLIVRLNELG
260 270 280 290 300
AMNGVGRLDM IENRVVGIKS REIYEAPAAT ILHFAHRELE RLTLEKSVFQ
310 320 330 340 350
YKRNIGQDYA NLIYNGTWFS PMRKALDAFV DETQKPVTGM VRIKLYKGSM
360 370 380 390 400
TLLGRTSPNS LYNEALATYT EADTFDHKSA EGFIKIYGLG LKTFHEVNKS

E
Length:401
Mass (Da):44,423
Last modified:October 1, 2002 - v1
Checksum:i4ECE7F2DEC336A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72347.1
RefSeqiNP_662005.1, NC_002932.3
WP_010932792.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72347; AAM72347; CT1114
GeneIDi1006894
KEGGicte:CT1114
PATRICifig|194439.7.peg.1012

Similar proteinsi

Entry informationi

Entry nameiASSY_CHLTE
AccessioniPrimary (citable) accession number: Q8KDE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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