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Q8KCW4

- IMDH_CHLTE

UniProt

Q8KCW4 - IMDH_CHLTE

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, CT1293
Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei251 – 2511NAD By similarity
Metal bindingi303 – 3031Potassium; via carbonyl oxygen By similarity
Metal bindingi305 – 3051Potassium; via carbonyl oxygen By similarity
Binding sitei306 – 3061IMP By similarity
Active sitei308 – 3081Thioimidate intermediate By similarity
Metal bindingi308 – 3081Potassium; via carbonyl oxygen By similarity
Binding sitei421 – 4211IMP By similarity
Metal bindingi475 – 4751Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi476 – 4761Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi477 – 4771Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi301 – 3033NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1329-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:CT1293
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000093693Add
BLAST

Proteomic databases

PRIDEiQ8KCW4.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT1293.

Structurei

3D structure databases

ProteinModelPortaliQ8KCW4.
SMRiQ8KCW4. Positions 2-491.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 15462CBS 1
Add
BLAST
Domaini158 – 21760CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni341 – 3433IMP binding By similarity
Regioni364 – 3652IMP binding By similarity
Regioni388 – 3925IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
HOGENOMiHOG000165755.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KCW4-1 [UniParc]FASTAAdd to Basket

« Hide

MDKILYDALT FDDVLLVPAY SNVLPKETVV KSRLTRQIEV NIPLVSAAMD    50
TVTEAELAIA LARAGGIGII HKNLSIDEQA RQVAKVKRFE SGIIRNPIHL 100
FEDATIQDAI DLMIRHSISG IPVVEHPTPE GCLLLKGIVT NRDLRMTASS 150
DEKITTIMTT NLVTAKEGID LLTAEDILMR NKIEKLLIID DNGYLKGLIT 200
FKDIQKRKQC PDACKDSQGR LRAGAAVGIR ANTMSRVDAL VAAGVDVVAV 250
DTAHGHSQAV LDMVATIKQK YPELQVIAGN VATPEAVRDL VKAGADAVKV 300
GIGPGSICTT RIVAGVGMPQ LTAIMKCAEE AKKTDIPLIA DGGIKYSGDI 350
AKALAAGADS VMMGSVFAGT DESPGETILY EGRRFKAYRG MGSLGAMSEP 400
EGSSDRYFQD VSAETKKYVP EGIEGRIPAK GKLDEVVYQL IGGLKSAMGY 450
CGVRTITELK ENTRFVRITS AGLRESHPHD VMITKEAPNY STSA 494
Length:494
Mass (Da):53,019
Last modified:October 1, 2002 - v1
Checksum:iCD4C06DBBCB724DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72523.1.
RefSeqiNP_662181.1. NC_002932.3.
WP_010932962.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72523; AAM72523; CT1293.
GeneIDi1006653.
KEGGicte:CT1293.
PATRICi21400541. VBIChlTep116050_1178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72523.1 .
RefSeqi NP_662181.1. NC_002932.3.
WP_010932962.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KCW4.
SMRi Q8KCW4. Positions 2-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT1293.

Proteomic databases

PRIDEi Q8KCW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM72523 ; AAM72523 ; CT1293 .
GeneIDi 1006653.
KEGGi cte:CT1293.
PATRICi 21400541. VBIChlTep116050_1178.

Phylogenomic databases

eggNOGi COG0517.
HOGENOMi HOG000165755.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci CTEP194439:GHN0-1329-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiIMDH_CHLTE
AccessioniPrimary (citable) accession number: Q8KCW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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