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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi305Magnesium or manganese 1UniRule annotation1
Metal bindingi319Magnesium or manganese 1UniRule annotation1
Metal bindingi319Magnesium or manganese 2UniRule annotation1
Metal bindingi321Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 234ATPUniRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1383-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Synonyms:ddlA
Ordered Locus Names:CT1345
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001778031 – 364D-alanine--D-alanine ligaseAdd BLAST364

Proteomic databases

PRIDEiQ8KCR8

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1345

Structurei

3D structure databases

ProteinModelPortaliQ8KCR8
SMRiQ8KCR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 352ATP-graspUniRule annotationAdd BLAST207

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011593
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KCR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQTVALFF GGKSAEHEIS IISARSIAAQ IDRNRYELSP LYIDRDGKWH
60 70 80 90 100
ASECSQQVLD TDIAALLRSG TPESAGKRLD ELTAAAAGEC FDFGSFLKNT
110 120 130 140 150
DVAFIALHGS YGEDGKLQGC LDTFGIPYTG CGLTASALAM DKVLTKLCAM
160 170 180 190 200
NAGIAVAEFM TITSCAYMAN PLETIVEITK RFDWPLFVKP ASLGSSVGIS
210 220 230 240 250
KVRNAEELAA ALENACGLDS KALVEAAISG REIEVAVLGN SDPLASEPGE
260 270 280 290 300
IIPGSDFYSY EDKYIKNEAK IVIPADLPEG VAEEVRKAAL TVFKALGCEG
310 320 330 340 350
MARVDFFVEN GTNRVILNEI NTIPGFTDIS MYPMMMAASG IGFAELVEKL
360
LLLALEKRSI THKI
Length:364
Mass (Da):39,033
Last modified:October 1, 2002 - v1
Checksum:iC8565880E5A01F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72574.1
RefSeqiNP_662232.1, NC_002932.3
WP_010933013.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72574; AAM72574; CT1345
GeneIDi1006715
KEGGicte:CT1345
PATRICifig|194439.7.peg.1224

Similar proteinsi

Entry informationi

Entry nameiDDL_CHLTE
AccessioniPrimary (citable) accession number: Q8KCR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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