Q8KCP5 (Q8KCP5_CHLTE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL AAM72597.1
Ordered Locus Names:	CT1368

Organism

Chlorobium tepidum

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8KCP5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 429A6C63E7404041	FASTA	290	32,773
	10 20 30 40 50 60 MLVKEIFDAR TEPVFSLEFF PPKKQDDWDK LFETISNLFP LDPSYVSVTY GAGGSTRERT 70 80 90 100 110 120 HNLVTRIQQE TGLTVVSHLT CIGAEKSEIE SVLQNYREHG ITNVLALRGD KPADITTLEE 130 140 150 160 170 180 ATKDFPHAID LVKFIKENFP EMGIGVAGFP EGHPETPNRM KELEFLKEKV DAGADYIVTQ 190 200 210 220 230 240 LFFDNHDYFD YVERCELAGI TVPIIPGIMP IMSKKGMIRM CELALGSRIP SKLLRKVLEA 250 260 270 280 290 ADDKEVAEIG VEWATNQVQE LLDHKVKGVH FYTLNLSEAT LKIFRNLKRG

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006470 Genomic DNA. Translation: AAM72597.1.
RefSeq	NP_662255.1. NC_002932.3.
3D structure databases
HSSP	HSSP built from PDB template 1B5T based on UniProtKB P00394.
ProteinModelPortal	Q8KCP5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1006746.
GenomeReviews	Gene locus CT1368 in contig AE006470_GR.
KEGG	cte:CT1368.
NMPDR	fig|194439.1.peg.1349.
PATRIC	21400679. VBIChlTep116050_1245.
TIGR	CT1368.
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK637732.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8KCP5_CHLTE

Accession

Primary (citable) accession number: Q8KCP5

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)