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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

dipyrromethaneUniRule annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Porphobilinogen deaminase (hemC)
  3. Uroporphyrinogen-III synthase (hemD)
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayi: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processChlorophyll biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1466-MONOMER
UniPathwayiUPA00251; UER00319
UPA00668

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:CT1427
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001429221 – 312Porphobilinogen deaminaseAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241S-(dipyrrolylmethanemethyl)cysteineUniRule annotation1

Proteomic databases

PRIDEiQ8KCJ4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT1427

Structurei

3D structure databases

ProteinModelPortaliQ8KCJ4
SMRiQ8KCJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6W Bacteria
COG0181 LUCA
HOGENOMiHOG000228587
KOiK01749
OMAiCQVPIGV
OrthoDBiPOG091H064B

Family and domain databases

Gene3Di3.30.160.40, 1 hit
HAMAPiMF_00260 Porphobil_deam, 1 hit
InterProiView protein in InterPro
IPR000860 HemC
IPR022419 Porphobilin_deaminase_cofac_BS
IPR022417 Porphobilin_deaminase_N
IPR022418 Porphobilinogen_deaminase_C
IPR036803 Porphobilinogen_deaminase_C_sf
PANTHERiPTHR11557 PTHR11557, 1 hit
PfamiView protein in Pfam
PF01379 Porphobil_deam, 1 hit
PF03900 Porphobil_deamC, 1 hit
PIRSFiPIRSF001438 4pyrrol_synth_OHMeBilane_synth, 1 hit
PRINTSiPR00151 PORPHBDMNASE
SUPFAMiSSF54782 SSF54782, 1 hit
TIGRFAMsiTIGR00212 hemC, 1 hit
PROSITEiView protein in PROSITE
PS00533 PORPHOBILINOGEN_DEAM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KCJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKELIIGTR SSPLALWQAE FTKAELSRHF PELNITLKLV KTTGDVLLDS
60 70 80 90 100
PLSKIGDMGL FTKDIEKHLL AKEIDLAVHS LKDVPTGTPE GLVISSFTKR
110 120 130 140 150
EDTRDVIISK SGKGLKDLPP NARMATSSLR RMSQLLSMRP DLQILDIRGN
160 170 180 190 200
LNTRFKKFDD GEFDAMMLAY AGVYRLEFSD RISEILPHDV MLPAVGQGAL
210 220 230 240 250
GIETRTDDAE TIEIVRVMND SNTEICCRAE RALLRHLQGG CQIPIGCYGS
260 270 280 290 300
YISGTLKLLA FVGSVDGKTA LRNELTKPVN TPEEAEAVGI ELAEVLLSMG
310
AEKILADIRK TR
Length:312
Mass (Da):34,394
Last modified:October 1, 2002 - v1
Checksum:i235B5141D59B0C6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72655.1
RefSeqiNP_662313.1, NC_002932.3
WP_010933094.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72655; AAM72655; CT1427
GeneIDi1005971
KEGGicte:CT1427
PATRICifig|194439.7.peg.1295

Similar proteinsi

Entry informationi

Entry nameiHEM3_CHLTE
AccessioniPrimary (citable) accession number: Q8KCJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health