Q8KCJ3 (HEM4_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen-III synthase
Short name=UROS
EC=4.2.1.75

Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Gene names

Name:	hemD
Ordered Locus Names:	CT1428

Organism

Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]

Taxonomic identifier

194439 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum › Chlorobaculum tepidum

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.
Catalytic activity	Hydroxymethylbilane = uroporphyrinogen III + H2O.
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
Sequence similarities	Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Uroporphyrinogen-III synthase		PRO_0000135241

Sequences

	Sequence		Length	Mass (Da)
	Q8KCJ3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: E45E4C7BA7F75AC0	FASTA	246	26,616
	10 20 30 40 50 60 MKTVLVTRPK HQAEPFVREL AQYGLDSVVF PTIEIRPVTG WSVPDLTRFA GIFFTSPNSV 70 80 90 100 110 120 QFFLERLLEE SPDELPNLQQ ARVWAVGKTT GGDLEKHGVS IEPLPKSADA VSLMSGIDAS 130 140 150 160 170 180 EIEGKTFLFV RGSLSLGTIP EVIAKRGGIC VELTVYDNIQ PSLEETQKIK SLLTEGKIDC 190 200 210 220 230 240 LSFTSPSTAI NFFEAIDSKE VPSDVLIAAI GTTTSSALEK LGVKVDIIPE YFDGPNFAKA IAAALS

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006470 Genomic DNA. Translation: AAM72656.1.
RefSeq	NP_662314.1. NC_002932.3.
3D structure databases
ProteinModelPortal	Q8KCJ3.
ModBase	Search...
Protein-protein interaction databases
STRING	194439.CT1428.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM72656; AAM72656; CT1428.
GeneID	1005977.
KEGG	cte:CT1428.
PATRIC	21400783. VBIChlTep116050_1296.
Phylogenomic databases
eggNOG	COG1587.
HOGENOM	HOG000152969.
KO	K01719.
OMA	VDIIPEY.
ProtClustDB	CLSK637759.
Enzyme and pathway databases
BioCyc	CTEP194439:GHN0-1467-MONOMER.
UniPathway	UPA00251; UER00320.
Family and domain databases
InterPro	IPR003754. 4pyrrol_synth_uPrphyn_synth. [Graphical view]
Pfam	PF02602. HEM4. 1 hit. [Graphical view]
SUPFAM	SSF69618. HEM4_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEM4_CHLTE

Accession

Primary (citable) accession number: Q8KCJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program