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Q8KCJ3 (HEM4_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III synthase

Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Name:hemD
Ordered Locus Names:CT1428
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionuroporphyrinogen-III synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Uroporphyrinogen-III synthase
PRO_0000135241

Sequences

Sequence LengthMass (Da)Tools
Q8KCJ3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E45E4C7BA7F75AC0

FASTA24626,616
        10         20         30         40         50         60 
MKTVLVTRPK HQAEPFVREL AQYGLDSVVF PTIEIRPVTG WSVPDLTRFA GIFFTSPNSV 

        70         80         90        100        110        120 
QFFLERLLEE SPDELPNLQQ ARVWAVGKTT GGDLEKHGVS IEPLPKSADA VSLMSGIDAS 

       130        140        150        160        170        180 
EIEGKTFLFV RGSLSLGTIP EVIAKRGGIC VELTVYDNIQ PSLEETQKIK SLLTEGKIDC 

       190        200        210        220        230        240 
LSFTSPSTAI NFFEAIDSKE VPSDVLIAAI GTTTSSALEK LGVKVDIIPE YFDGPNFAKA 


IAAALS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM72656.1.
RefSeqNP_662314.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KCJ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT1428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM72656; AAM72656; CT1428.
GeneID1005977.
KEGGcte:CT1428.
PATRIC21400783. VBIChlTep116050_1296.

Phylogenomic databases

eggNOGCOG1587.
HOGENOMHOG000152969.
KOK01719.
OMADCLSFTS.
OrthoDBEOG6JQH1B.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-1467-MONOMER.
UniPathwayUPA00251; UER00320.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. SSF69618. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEM4_CHLTE
AccessionPrimary (citable) accession number: Q8KCJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways