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Q8KCJ3

- HEM4_CHLTE

UniProt

Q8KCJ3 - HEM4_CHLTE

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Protein

Uroporphyrinogen-III synthase

Gene
hemD, CT1428
Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1467-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:CT1428
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1428.

Structurei

3D structure databases

ProteinModelPortaliQ8KCJ3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000152969.
KOiK01719.
OMAiDCLSFTS.
OrthoDBiEOG6JQH1B.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KCJ3-1 [UniParc]FASTAAdd to Basket

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MKTVLVTRPK HQAEPFVREL AQYGLDSVVF PTIEIRPVTG WSVPDLTRFA    50
GIFFTSPNSV QFFLERLLEE SPDELPNLQQ ARVWAVGKTT GGDLEKHGVS 100
IEPLPKSADA VSLMSGIDAS EIEGKTFLFV RGSLSLGTIP EVIAKRGGIC 150
VELTVYDNIQ PSLEETQKIK SLLTEGKIDC LSFTSPSTAI NFFEAIDSKE 200
VPSDVLIAAI GTTTSSALEK LGVKVDIIPE YFDGPNFAKA IAAALS 246
Length:246
Mass (Da):26,616
Last modified:October 1, 2002 - v1
Checksum:iE45E4C7BA7F75AC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72656.1.
RefSeqiNP_662314.1. NC_002932.3.
WP_010933095.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72656; AAM72656; CT1428.
GeneIDi1005977.
KEGGicte:CT1428.
PATRICi21400783. VBIChlTep116050_1296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72656.1 .
RefSeqi NP_662314.1. NC_002932.3.
WP_010933095.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KCJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT1428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM72656 ; AAM72656 ; CT1428 .
GeneIDi 1005977.
KEGGi cte:CT1428.
PATRICi 21400783. VBIChlTep116050_1296.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000152969.
KOi K01719.
OMAi DCLSFTS.
OrthoDBi EOG6JQH1B.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci CTEP194439:GHN0-1467-MONOMER.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiHEM4_CHLTE
AccessioniPrimary (citable) accession number: Q8KCJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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