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Q8KCJ3

- HEM4_CHLTE

UniProt

Q8KCJ3 - HEM4_CHLTE

Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciCTEP194439:GHN0-1467-MONOMER.
    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:hemD
    Ordered Locus Names:CT1428
    OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
    Taxonomic identifieri194439 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
    ProteomesiUP000001007: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135241Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi194439.CT1428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KCJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000152969.
    KOiK01719.
    OMAiDCLSFTS.
    OrthoDBiEOG6JQH1B.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8KCJ3-1 [UniParc]FASTAAdd to Basket

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    MKTVLVTRPK HQAEPFVREL AQYGLDSVVF PTIEIRPVTG WSVPDLTRFA    50
    GIFFTSPNSV QFFLERLLEE SPDELPNLQQ ARVWAVGKTT GGDLEKHGVS 100
    IEPLPKSADA VSLMSGIDAS EIEGKTFLFV RGSLSLGTIP EVIAKRGGIC 150
    VELTVYDNIQ PSLEETQKIK SLLTEGKIDC LSFTSPSTAI NFFEAIDSKE 200
    VPSDVLIAAI GTTTSSALEK LGVKVDIIPE YFDGPNFAKA IAAALS 246
    Length:246
    Mass (Da):26,616
    Last modified:October 1, 2002 - v1
    Checksum:iE45E4C7BA7F75AC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM72656.1.
    RefSeqiNP_662314.1. NC_002932.3.
    WP_010933095.1. NC_002932.3.

    Genome annotation databases

    EnsemblBacteriaiAAM72656; AAM72656; CT1428.
    GeneIDi1005977.
    KEGGicte:CT1428.
    PATRICi21400783. VBIChlTep116050_1296.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM72656.1 .
    RefSeqi NP_662314.1. NC_002932.3.
    WP_010933095.1. NC_002932.3.

    3D structure databases

    ProteinModelPortali Q8KCJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 194439.CT1428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM72656 ; AAM72656 ; CT1428 .
    GeneIDi 1005977.
    KEGGi cte:CT1428.
    PATRICi 21400783. VBIChlTep116050_1296.

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000152969.
    KOi K01719.
    OMAi DCLSFTS.
    OrthoDBi EOG6JQH1B.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    BioCyci CTEP194439:GHN0-1467-MONOMER.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49652 / DSM 12025 / TLS.

    Entry informationi

    Entry nameiHEM4_CHLTE
    AccessioniPrimary (citable) accession number: Q8KCJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3