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Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1467-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:CT1428
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1428.

Structurei

3D structure databases

ProteinModelPortaliQ8KCJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000152969.
KOiK01719.
OMAiVWAVGKT.
OrthoDBiEOG6JQH1B.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KCJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVLVTRPK HQAEPFVREL AQYGLDSVVF PTIEIRPVTG WSVPDLTRFA
60 70 80 90 100
GIFFTSPNSV QFFLERLLEE SPDELPNLQQ ARVWAVGKTT GGDLEKHGVS
110 120 130 140 150
IEPLPKSADA VSLMSGIDAS EIEGKTFLFV RGSLSLGTIP EVIAKRGGIC
160 170 180 190 200
VELTVYDNIQ PSLEETQKIK SLLTEGKIDC LSFTSPSTAI NFFEAIDSKE
210 220 230 240
VPSDVLIAAI GTTTSSALEK LGVKVDIIPE YFDGPNFAKA IAAALS
Length:246
Mass (Da):26,616
Last modified:September 30, 2002 - v1
Checksum:iE45E4C7BA7F75AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72656.1.
RefSeqiNP_662314.1. NC_002932.3.
WP_010933095.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72656; AAM72656; CT1428.
GeneIDi1005977.
KEGGicte:CT1428.
PATRICi21400783. VBIChlTep116050_1296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72656.1.
RefSeqiNP_662314.1. NC_002932.3.
WP_010933095.1. NC_002932.3.

3D structure databases

ProteinModelPortaliQ8KCJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi194439.CT1428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM72656; AAM72656; CT1428.
GeneIDi1005977.
KEGGicte:CT1428.
PATRICi21400783. VBIChlTep116050_1296.

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000152969.
KOiK01719.
OMAiVWAVGKT.
OrthoDBiEOG6JQH1B.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.
BioCyciCTEP194439:GHN0-1467-MONOMER.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiHEM4_CHLTE
AccessioniPrimary (citable) accession number: Q8KCJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2002
Last sequence update: September 30, 2002
Last modified: March 31, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.