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Q8KCI9

- AROC_CHLTE

UniProt

Q8KCI9 - AROC_CHLTE

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Protein

Chorismate synthase

Gene

aroC

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.UniRule annotation

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.UniRule annotation

Cofactori

FMNH2UniRule annotationNote: Reduced FMN (FMNH(2)).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401NADPUniRule annotation
Binding sitei46 – 461NADPUniRule annotation
Binding sitei302 – 3021FMN; via amide nitrogenUniRule annotation
Binding sitei343 – 3431FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi129 – 1313FMNUniRule annotation
Nucleotide bindingi257 – 2582FMNUniRule annotation
Nucleotide bindingi317 – 3215FMNUniRule annotation

GO - Molecular functioni

  1. chorismate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1471-MONOMER.
UniPathwayiUPA00053; UER00090.

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthaseUniRule annotation (EC:4.2.3.5UniRule annotation)
Short name:
CSUniRule annotation
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyaseUniRule annotation
Gene namesi
Name:aroCUniRule annotation
Ordered Locus Names:CT1432
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Chorismate synthasePRO_0000140574Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT1432.

Structurei

3D structure databases

ProteinModelPortaliQ8KCI9.
SMRiQ8KCI9. Positions 1-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0082.
HOGENOMiHOG000060334.
KOiK01736.
OMAiYMRDLKK.
OrthoDBiEOG6WDSHT.

Family and domain databases

Gene3Di3.60.150.10. 1 hit.
HAMAPiMF_00300. Chorismate_synth.
InterProiIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
PANTHERiPTHR21085. PTHR21085. 1 hit.
PfamiPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMiSSF103263. SSF103263. 1 hit.
TIGRFAMsiTIGR00033. aroC. 1 hit.
PROSITEiPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KCI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRYFTAGES HGPALSAIVE GMPAGVALTE SDINDQLARR QQGYGRGGRM
60 70 80 90 100
KIETDRAEVL SGVRFGKTIG SPVAMLIRNR DWENWTTSMA QFEDHATEVQ
110 120 130 140 150
KITIPRPGHA DLTGFVKYGF DDIRPVIDRS SARETAARVA AGSLARAFLR
160 170 180 190 200
QLGIQIGSYI STIGPVSEAA APASLQELLD AGAESLAAEA DKSPVRMLDP
210 220 230 240 250
EAETAAIAAI DQAKADGDTL GGIVELYITG VPMGLGSYVQ HDRRLDSELA
260 270 280 290 300
AAIMSIQAIK GVEIGPAFDN ARKPGSQVHD ELFAGGEKGL RRETNRAGGI
310 320 330 340 350
EGSMSSGQPI HIRAAMKPIS SLVSPLSSFD LATLEAVQSR FERSDTCAVP
360 370 380 390
AAGVVAEAVV APVIANALLE KLGGDHMAEI KERLEVYRAA LRMRFEK
Length:397
Mass (Da):42,278
Last modified:October 1, 2002 - v1
Checksum:i2D556ACD8B85217A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72660.1.
RefSeqiNP_662318.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72660; AAM72660; CT1432.
GeneIDi1005980.
KEGGicte:CT1432.
PATRICi21400791. VBIChlTep116050_1300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72660.1 .
RefSeqi NP_662318.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KCI9.
SMRi Q8KCI9. Positions 1-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT1432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM72660 ; AAM72660 ; CT1432 .
GeneIDi 1005980.
KEGGi cte:CT1432.
PATRICi 21400791. VBIChlTep116050_1300.

Phylogenomic databases

eggNOGi COG0082.
HOGENOMi HOG000060334.
KOi K01736.
OMAi YMRDLKK.
OrthoDBi EOG6WDSHT.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00090 .
BioCyci CTEP194439:GHN0-1471-MONOMER.

Family and domain databases

Gene3Di 3.60.150.10. 1 hit.
HAMAPi MF_00300. Chorismate_synth.
InterProi IPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view ]
PANTHERi PTHR21085. PTHR21085. 1 hit.
Pfami PF01264. Chorismate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001456. Chorismate_synth. 1 hit.
SUPFAMi SSF103263. SSF103263. 1 hit.
TIGRFAMsi TIGR00033. aroC. 1 hit.
PROSITEi PS00787. CHORISMATE_SYNTHASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiAROC_CHLTE
AccessioniPrimary (citable) accession number: Q8KCI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3