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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1492-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:CT1453
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829461 – 314Methionyl-tRNA formyltransferaseAdd BLAST314

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1453

Structurei

3D structure databases

ProteinModelPortaliQ8KCG8
SMRiQ8KCG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KCG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRVVFMGT PEFAVPSLRR IAAMKPQFET VLVVTGCDKP RRSKNSPPEP
60 70 80 90 100
TPVKQAALEL GLPVLEADDV SSHEFALQVA AARPDVIVVA AFRVLPPEVL
110 120 130 140 150
ELPPLGTFNL HGSLLPAYRG AAPVNWAIIN GDAETGVTTF FLQKSVDTGN
160 170 180 190 200
IITMDRTPIG PDENAFELLK RLSEIGAGTV ERTLTMIADG AVMPEKQDER
210 220 230 240 250
FATKAPKLNR ENTRIDWNQP VQRLHDFIRG LALKPAAWTT FGGKSLKIYK
260 270 280 290 300
AKACAIETAP DEPGTLRIAD GRLLVAGTDG WIELLSVQAE GKKAMDGELF
310
ARGLRARKEM LRFL
Length:314
Mass (Da):34,244
Last modified:October 1, 2002 - v1
Checksum:iBC8A66A944591236
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72681.1
RefSeqiNP_662339.1, NC_002932.3
WP_010933120.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72681; AAM72681; CT1453
GeneIDi1006000
KEGGicte:CT1453
PATRICifig|194439.7.peg.1318

Similar proteinsi

Entry informationi

Entry nameiFMT_CHLTE
AccessioniPrimary (citable) accession number: Q8KCG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health