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Protein

Peptide deformylase

Gene

def

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi94IronUniRule annotation1
Metal bindingi136IronUniRule annotation1
Active sitei137UniRule annotation1
Metal bindingi140IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1493-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:CT1454
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827631 – 187Peptide deformylaseAdd BLAST187

Proteomic databases

PRIDEiQ8KCG7

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1454

Structurei

3D structure databases

ProteinModelPortaliQ8KCG7
SMRiQ8KCG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243509
KOiK01462
OMAiVCIQHEI
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KCG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILPINTYSD PVLAMKAKPL KGVDSAIEEL IAEMFDTMYK APGIGLAAPQ
60 70 80 90 100
VGHSLRLVVV DISTIKEYAD FKPMVVINPR IVAVRGRSLM EEGCLSVPGI
110 120 130 140 150
AGNVVRPSAI TLHYRDEKFE EHTADFHSMM ARVLQHEIDH LDGTLFVDRM
160 170 180
DKRDRRKIQK ELDAIAEGRV KADYPLARDV NRVEAEA
Length:187
Mass (Da):20,909
Last modified:October 1, 2002 - v1
Checksum:i1E16EA5077AFC296
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72682.1
RefSeqiNP_662340.1, NC_002932.3
WP_010933121.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72682; AAM72682; CT1454
GeneIDi1006001
KEGGicte:CT1454
PATRICifig|194439.7.peg.1319

Similar proteinsi

Entry informationi

Entry nameiDEF_CHLTE
AccessioniPrimary (citable) accession number: Q8KCG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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