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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei154S-adenosyl-L-methionineUniRule annotation1
Binding sitei202S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Synonyms:hemK
Ordered Locus Names:CT1487
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145101 – 294Release factor glutamine methyltransferaseAdd BLAST294

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1487.

Structurei

3D structure databases

ProteinModelPortaliQ8KCD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 135S-adenosyl-L-methionine bindingUniRule annotation5
Regioni202 – 205Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076274.
KOiK02493.
OMAiQYCTNKA.
OrthoDBiPOG091H02CJ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR025714. Methyltranfer_dom.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KCD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEKVWSVV ELLKTTIAFF AEKKIDEPRL SAELLLGHVL GLQRLQLYLD
60 70 80 90 100
HERPLTLKEL EAFRAACRER LQGRPVQYIA GEAFFYGYQF FVDERVLIPR
110 120 130 140 150
PETELVLEHA MERLAASGLD SADSPSILDV GTGSGCIAIT LALRLPGARV
160 170 180 190 200
TAADVSADAL DVARRNADAH GVSERIRFVE ADALSASFAD AVGGPFDLLV
210 220 230 240 250
SNPPYIPEAE WATLQEEVRR YEPRLALVAP TGFEYYQSIA VAAPSLLRKG
260 270 280 290
GVLCFELHAD GAAEVRNLLG SSFADVQVMQ DYNKLDRGLS CMAQ
Length:294
Mass (Da):32,308
Last modified:October 1, 2002 - v1
Checksum:iB361FBBE855DACA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72714.1.
RefSeqiNP_662372.1. NC_002932.3.
WP_010933153.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72714; AAM72714; CT1487.
GeneIDi1006032.
KEGGicte:CT1487.
PATRICi21400889. VBIChlTep116050_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72714.1.
RefSeqiNP_662372.1. NC_002932.3.
WP_010933153.1. NC_002932.3.

3D structure databases

ProteinModelPortaliQ8KCD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi194439.CT1487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM72714; AAM72714; CT1487.
GeneIDi1006032.
KEGGicte:CT1487.
PATRICi21400889. VBIChlTep116050_1349.

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076274.
KOiK02493.
OMAiQYCTNKA.
OrthoDBiPOG091H02CJ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR025714. Methyltranfer_dom.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRMC_CHLTE
AccessioniPrimary (citable) accession number: Q8KCD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.