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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N5-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei154S-adenosyl-L-methionineUniRule annotation1
Binding sitei202S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1526-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Synonyms:hemK
Ordered Locus Names:CT1487
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145101 – 294Release factor glutamine methyltransferaseAdd BLAST294

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1487

Structurei

3D structure databases

ProteinModelPortaliQ8KCD5
SMRiQ8KCD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 135S-adenosyl-L-methionine bindingUniRule annotation5
Regioni202 – 205Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY Bacteria
COG2890 LUCA
HOGENOMiHOG000076274
KOiK02493
OMAiMLVSNPP
OrthoDBiPOG091H02CJ

Family and domain databases

HAMAPiMF_02126 RF_methyltr_PrmC, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR025714 Methyltranfer_dom
IPR004556 Modification_methylase_HemK
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF13847 Methyltransf_31, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KCD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEKVWSVV ELLKTTIAFF AEKKIDEPRL SAELLLGHVL GLQRLQLYLD
60 70 80 90 100
HERPLTLKEL EAFRAACRER LQGRPVQYIA GEAFFYGYQF FVDERVLIPR
110 120 130 140 150
PETELVLEHA MERLAASGLD SADSPSILDV GTGSGCIAIT LALRLPGARV
160 170 180 190 200
TAADVSADAL DVARRNADAH GVSERIRFVE ADALSASFAD AVGGPFDLLV
210 220 230 240 250
SNPPYIPEAE WATLQEEVRR YEPRLALVAP TGFEYYQSIA VAAPSLLRKG
260 270 280 290
GVLCFELHAD GAAEVRNLLG SSFADVQVMQ DYNKLDRGLS CMAQ
Length:294
Mass (Da):32,308
Last modified:October 1, 2002 - v1
Checksum:iB361FBBE855DACA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72714.1
RefSeqiNP_662372.1, NC_002932.3
WP_010933153.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72714; AAM72714; CT1487
GeneIDi1006032
KEGGicte:CT1487
PATRICifig|194439.7.peg.1349

Similar proteinsi

Entry informationi

Entry nameiPRMC_CHLTE
AccessioniPrimary (citable) accession number: Q8KCD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health