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Q8KCC7 (ISPE_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Short name=CMK
EC=2.7.1.148
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene names
Name:ispE
Ordered Locus Names:CT1495
OrganismChlorobium tepidum
Taxonomic identifier1097 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2862864-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
PRO_0000189204

Regions

Nucleotide binding93 – 10311ATP Potential

Sites

Active site111 By similarity
Active site1351 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KCC7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8DA0213625CD818C

FASTA28631,409
        10         20         30         40         50         60 
MKHFSVKACA KINLGLLITS RRADGYHTLE TIFAPIDWFD TLEFTESDAI SMECSNLDLL 

        70         80         90        100        110        120 
VDDSNLCIRA AKALQEHTGV KRGATIKLLK RVPFGAGLGG GSSDAAATLN ALCKLWQIDV 

       130        140        150        160        170        180 
PSAELHKLAV KLGADVPYFL EMKGLAYAAG IGEELEDLNL ALPWHVVTVF PEVQVPTAWA 

       190        200        210        220        230        240 
YKNFHRQFER PVPDLKTLVR RLCHERDISV FGVFENDFAS VVFEHYPVVR EVRDALAASG 

       250        260        270        280 
AQFVSLSGSG SAVYALYEGR ADAVKAAEAM SARFRINMTP AGFRME

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006470 Genomic DNA. Translation: AAM72722.1.
RefSeqNP_662380.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KCC7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1007666.
GenomeReviewsGene locus CT1495 in contig AE006470_GR.
KEGGcte:CT1495.
NMPDRfig|194439.1.peg.1474.
PATRIC21400903. VBIChlTep116050_1356.
TIGRCT1495.

Phylogenomic databases

HOGENOMHBG734593.
OMAVSTAEVY.
ProtClustDBPRK14616.

Enzyme and pathway databases

BioCycCTEP194439:CT_1495-MONOMER.

Family and domain databases

HAMAPMF_00061. IspE.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00919.
PANTHERPTHR20861:SF2. IspE. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. IspE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPE_CHLTE
AccessionPrimary (citable) accession number: Q8KCC7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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