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Q8KCB2

- FENR_CHLTE

UniProt

Q8KCB2 - FENR_CHLTE

Protein

Ferredoxin--NADP reductase

Gene

CT1512

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.1 Publication

    Cofactori

    Binds 1 FAD per subunit.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei25 – 251FADBy similarity
    Binding sitei44 – 441FADBy similarity
    Binding sitei52 – 521FADBy similarity
    Binding sitei57 – 571FADBy similarity
    Binding sitei97 – 971FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei132 – 1321FAD; via amide nitrogenBy similarity
    Binding sitei298 – 2981FADBy similarity
    Binding sitei339 – 3391FADBy similarity

    GO - Molecular functioni

    1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciCTEP194439:GHN0-1551-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferredoxin--NADP reductase (EC:1.18.1.2)
    Short name:
    FNR
    Short name:
    Fd-NADP(+) reductase
    Gene namesi
    Ordered Locus Names:CT1512
    OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
    Taxonomic identifieri194439 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
    ProteomesiUP000001007: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Ferredoxin--NADP reductasePRO_0000364821Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi194439.CT1512.

    Structurei

    Secondary structure

    1
    360
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi15 – 206
    Helixi24 – 3512
    Beta strandi40 – 434
    Beta strandi45 – 495
    Helixi51 – 555
    Beta strandi60 – 623
    Beta strandi69 – 724
    Helixi73 – 8513
    Beta strandi90 – 923
    Beta strandi97 – 1026
    Beta strandi108 – 1125
    Beta strandi117 – 1259
    Helixi138 – 1403
    Turni144 – 1463
    Turni148 – 1503
    Beta strandi151 – 1544
    Helixi158 – 1614
    Beta strandi165 – 1695
    Helixi173 – 1819
    Turni182 – 1854
    Beta strandi186 – 1927
    Beta strandi194 – 1974
    Helixi203 – 2064
    Helixi209 – 2135
    Beta strandi216 – 23116
    Beta strandi234 – 2429
    Beta strandi247 – 2515
    Beta strandi253 – 2575
    Helixi266 – 2705
    Beta strandi279 – 2813
    Beta strandi293 – 2953
    Helixi309 – 32719

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AB1X-ray2.39A/B1-360[»]
    ProteinModelPortaliQ8KCB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0492.
    HOGENOMiHOG000072909.
    KOiK00384.
    OMAiVIVNFGF.
    OrthoDBiEOG661H9M.

    Family and domain databases

    HAMAPiMF_01685. FENR2.
    InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR022890. Fd--NADP_Rdtase_type_2.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    PR00469. PNDRDTASEII.

    Sequencei

    Sequence statusi: Complete.

    Q8KCB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDIHNPATD HHDMRDLTII GGGPTGIFAA FQCGMNNISC RIIESMPQLG    50
    GQLAALYPEK HIYDVAGFPE VPAIDLVESL WAQAERYNPD VVLNETVTKY 100
    TKLDDGTFET RTNTGNVYRS RAVLIAAGLG AFEPRKLPQL GNIDHLTGSS 150
    VYYAVKSVED FKGKRVVIVG GGDSALDWTV GLIKNAASVT LVHRGHEFQG 200
    HGKTAHEVER ARANGTIDVY LETEVASIEE SNGVLTRVHL RSSDGSKWTV 250
    EADRLLILIG FKSNLGPLAR WDLELYENAL VVDSHMKTSV DGLYAAGDIA 300
    YYPGKLKIIQ TGLSEATMAV RHSLSYIKPG EKIRNVFSSV KMAKEKKAAE 350
    AGNATENKAE 360
    Length:360
    Mass (Da):39,240
    Last modified:October 1, 2002 - v1
    Checksum:iF016A6B0602475B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM72739.1.
    RefSeqiNP_662397.1. NC_002932.3.

    Genome annotation databases

    EnsemblBacteriaiAAM72739; AAM72739; CT1512.
    GeneIDi1006048.
    KEGGicte:CT1512.
    PATRICi21400935. VBIChlTep116050_1372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM72739.1 .
    RefSeqi NP_662397.1. NC_002932.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AB1 X-ray 2.39 A/B 1-360 [» ]
    ProteinModelPortali Q8KCB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 194439.CT1512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM72739 ; AAM72739 ; CT1512 .
    GeneIDi 1006048.
    KEGGi cte:CT1512.
    PATRICi 21400935. VBIChlTep116050_1372.

    Phylogenomic databases

    eggNOGi COG0492.
    HOGENOMi HOG000072909.
    KOi K00384.
    OMAi VIVNFGF.
    OrthoDBi EOG661H9M.

    Enzyme and pathway databases

    BioCyci CTEP194439:GHN0-1551-MONOMER.

    Family and domain databases

    HAMAPi MF_01685. FENR2.
    InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR022890. Fd--NADP_Rdtase_type_2.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    PR00469. PNDRDTASEII.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49652 / DSM 12025 / TLS.
    2. "Purification and characterization of ferredoxin-NAD(P)(+) reductase from the green sulfur bacterium Chlorobium tepidum."
      Seo D., Sakurai H.
      Biochim. Biophys. Acta 1597:123-132(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-25, CATALYTIC ACTIVITY, SUBUNIT, COFACTOR.

    Entry informationi

    Entry nameiFENR_CHLTE
    AccessioniPrimary (citable) accession number: Q8KCB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3