Reviewed, UniProtKB/Swiss-Prot Q8KC05 (GCSPA_CHLTE)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Synonyms:	gcvP1
Ordered Locus Names:	CT1625

Organism

Chlorobium tepidum [Complete proteome] [HAMAP]

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_0000166963

Sequences

	Sequence		Length	Mass (Da)
	Q8KC05-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 334273FF9723BB7F	FASTA	444	47,739
	10 20 30 40 50 60 MPFIVNTDAE RAEMLREIGV ENFEALIADI PEEIRLKKAL DLFPAMGEPE VKSLLEKMAS 70 80 90 100 110 120 GNAATCDHVS FLGAGAYDHF IPSAVKTIAS RSEFYTAYTP YQAEVSQGTL QAIYEYQSVM 130 140 150 160 170 180 CRLYGMDVAN ASMYDGASAL AEAALIALNV TGRNGIVVAG KLHPYTSQVL ETYLEAAGDR 190 200 210 220 230 240 SIVQNGLENG IGSVEALEAL VSSETAAVIV QQPNFYGCLE EVEAIGEIAR KNGALFIVSA 250 260 270 280 290 300 DPVSLGVLEA PGNYGADIAV GEGQSVGNAQ SFGGPYLGIL TVKQAHVRKI PGRLVGMTKD 310 320 330 340 350 360 KDGNDGFILT LQTREQHIRR EKATSNICSN QALCALQSVV HLSLLGKEGI RDVANRSMQK 370 380 390 400 410 420 AHYLADRIAE LPGYSMKFSA PFFREFVVET PVPSATIIEK MLEKKVFAGV DLSAWGEDGL 430 440 LVAVTEKRTK EELDSFVSEL AALG

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006470 Genomic DNA. Translation: AAM72850.1.
RefSeq	NP_662508.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1006116.
GenomeReviews	Gene locus CT1625 in contig AE006470_GR.
KEGG	cte:CT1625.
NMPDR	fig|194439.1.peg.1602.
TIGR	CT1625.
Phylogenomic databases
HOGENOM	Q8KC05.
OMA	Q8KC05. VANASMY.
Enzyme and pathway databases
BioCyc	CTEP194439:CT_1625-MON.
BRENDA	1.4.4.2. 189605.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_CHLTE

Accession

Primary (citable) accession number: Q8KC05

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)