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Q8KC05 (GCSPA_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Synonyms:gcvP1
Ordered Locus Names:CT1625
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166963

Sequences

Sequence LengthMass (Da)Tools
Q8KC05 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 334273FF9723BB7F

FASTA44447,739
        10         20         30         40         50         60 
MPFIVNTDAE RAEMLREIGV ENFEALIADI PEEIRLKKAL DLFPAMGEPE VKSLLEKMAS 

        70         80         90        100        110        120 
GNAATCDHVS FLGAGAYDHF IPSAVKTIAS RSEFYTAYTP YQAEVSQGTL QAIYEYQSVM 

       130        140        150        160        170        180 
CRLYGMDVAN ASMYDGASAL AEAALIALNV TGRNGIVVAG KLHPYTSQVL ETYLEAAGDR 

       190        200        210        220        230        240 
SIVQNGLENG IGSVEALEAL VSSETAAVIV QQPNFYGCLE EVEAIGEIAR KNGALFIVSA 

       250        260        270        280        290        300 
DPVSLGVLEA PGNYGADIAV GEGQSVGNAQ SFGGPYLGIL TVKQAHVRKI PGRLVGMTKD 

       310        320        330        340        350        360 
KDGNDGFILT LQTREQHIRR EKATSNICSN QALCALQSVV HLSLLGKEGI RDVANRSMQK 

       370        380        390        400        410        420 
AHYLADRIAE LPGYSMKFSA PFFREFVVET PVPSATIIEK MLEKKVFAGV DLSAWGEDGL 

       430        440 
LVAVTEKRTK EELDSFVSEL AALG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM72850.1.
RefSeqNP_662508.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KC05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT1625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM72850; AAM72850; CT1625.
GeneID1006116.
KEGGcte:CT1625.
PATRIC21401125. VBIChlTep116050_1467.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-1664-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_CHLTE
AccessionPrimary (citable) accession number: Q8KC05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families