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Q8KC05

- GCSPA_CHLTE

UniProt

Q8KC05 - GCSPA_CHLTE

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Synonyms:gcvP1
Ordered Locus Names:CT1625
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166963Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT1625.

Structurei

3D structure databases

ProteinModelPortaliQ8KC05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KC05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFIVNTDAE RAEMLREIGV ENFEALIADI PEEIRLKKAL DLFPAMGEPE
60 70 80 90 100
VKSLLEKMAS GNAATCDHVS FLGAGAYDHF IPSAVKTIAS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAIYEYQSVM CRLYGMDVAN ASMYDGASAL AEAALIALNV
160 170 180 190 200
TGRNGIVVAG KLHPYTSQVL ETYLEAAGDR SIVQNGLENG IGSVEALEAL
210 220 230 240 250
VSSETAAVIV QQPNFYGCLE EVEAIGEIAR KNGALFIVSA DPVSLGVLEA
260 270 280 290 300
PGNYGADIAV GEGQSVGNAQ SFGGPYLGIL TVKQAHVRKI PGRLVGMTKD
310 320 330 340 350
KDGNDGFILT LQTREQHIRR EKATSNICSN QALCALQSVV HLSLLGKEGI
360 370 380 390 400
RDVANRSMQK AHYLADRIAE LPGYSMKFSA PFFREFVVET PVPSATIIEK
410 420 430 440
MLEKKVFAGV DLSAWGEDGL LVAVTEKRTK EELDSFVSEL AALG
Length:444
Mass (Da):47,739
Last modified:October 1, 2002 - v1
Checksum:i334273FF9723BB7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72850.1.
RefSeqiNP_662508.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72850; AAM72850; CT1625.
GeneIDi1006116.
KEGGicte:CT1625.
PATRICi21401125. VBIChlTep116050_1467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM72850.1 .
RefSeqi NP_662508.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KC05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT1625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM72850 ; AAM72850 ; CT1625 .
GeneIDi 1006116.
KEGGi cte:CT1625.
PATRICi 21401125. VBIChlTep116050_1467.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CTEP194439:GHN0-1664-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiGCSPA_CHLTE
AccessioniPrimary (citable) accession number: Q8KC05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3