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Q8KBY3

- PNP_CHLTE

UniProt

Q8KBY3 - PNP_CHLTE

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi503 – 5031MagnesiumUniRule annotation
Metal bindingi509 – 5091MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CT1649
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Polyribonucleotide nucleotidyltransferasePRO_0000329587Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1649.

Structurei

3D structure databases

ProteinModelPortaliQ8KBY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 62960KHUniRule annotationAdd
BLAST
Domaini639 – 71375S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KBY3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFIKKKIDLG HGKVITIETG KMAKQADGSA VVTMNDTMVL ATVVSSKTPP
60 70 80 90 100
SPNQDFFPLQ VEYREKYSAA GKFPGGFFKR EGRPSEKEIL SARLIDRALR
110 120 130 140 150
PLFPDGYYQE TQIIISVISS DTINDADVLG GIAASAAIMV SDIPFANPMS
160 170 180 190 200
EVRVGRINGL FIVNPDINEL AQSDMDICIG GTEDTICMLE GEMKEISEAE
210 220 230 240 250
MLDAIKFGHD AIKKICALQR ELAAEVAKPK RPFSPTVAPD ELVNFVEEHC
260 270 280 290 300
SAELKALAYT PLAKEERAEK TKAIYTQTIR KTLTHFTDRV GPDQIEADPT
310 320 330 340 350
SAFCLNEHMI EECIHAVEKK VMRHMILDDG KRLDGRTLEQ VRPISIELGL
360 370 380 390 400
IPRAHGSALF TRGETQALVT LTLGTKKDAQ SVDTLTDDKD KRFMLHYNFP
410 420 430 440 450
PFSVGEIGRV GGAGRREIGH GNLAERAIKM VMPSEQEFPY TVRLVSDILE
460 470 480 490 500
SNGSSSMASV CGGTLAAMDG GIPLKKPVSG IAMGLIKEGD RYAVLSDILG
510 520 530 540 550
NEDHLGDMDF KVAGTRDGIT ACQMDIKIDG LDYHILETAL EQARKGRLHI
560 570 580 590 600
LDVMAEAIPE SRADIGKYAP RLTTIQIPVD AIGMVIGKGG ETIRSITEET
610 620 630 640 650
GAEINIDDDG TVTIACSSPE ATKAAVETIK TLVSKPEVGT IYMGKVRDIR
660 670 680 690 700
DELGAFVEFL PKTDGLVHIS EIARERIAKV SDVLKVGDRI KVKLIDVRKD
710 720 730
PRTGKTKFAL SIKALLDTDQ QAETNGEAKP ARD
Length:733
Mass (Da):79,938
Last modified:October 1, 2002 - v1
Checksum:i3C5D0C71E00C6AD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72874.1.
RefSeqiNP_662532.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72874; AAM72874; CT1649.
GeneIDi1006135.
KEGGicte:CT1649.
PATRICi21401173. VBIChlTep116050_1491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72874.1 .
RefSeqi NP_662532.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KBY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT1649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM72874 ; AAM72874 ; CT1649 .
GeneIDi 1006135.
KEGGi cte:CT1649.
PATRICi 21401173. VBIChlTep116050_1491.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CTEP194439:GHN0-1688-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiPNP_CHLTE
AccessioniPrimary (citable) accession number: Q8KBY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3