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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi503MagnesiumUniRule annotation1
Metal bindingi509MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1688-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CT1649
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295871 – 733Polyribonucleotide nucleotidyltransferaseAdd BLAST733

Proteomic databases

PRIDEiQ8KBY3

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1649

Structurei

3D structure databases

ProteinModelPortaliQ8KBY3
SMRiQ8KBY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini570 – 629KHUniRule annotationAdd BLAST60
Domaini639 – 713S1 motifUniRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KBY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKKKIDLG HGKVITIETG KMAKQADGSA VVTMNDTMVL ATVVSSKTPP
60 70 80 90 100
SPNQDFFPLQ VEYREKYSAA GKFPGGFFKR EGRPSEKEIL SARLIDRALR
110 120 130 140 150
PLFPDGYYQE TQIIISVISS DTINDADVLG GIAASAAIMV SDIPFANPMS
160 170 180 190 200
EVRVGRINGL FIVNPDINEL AQSDMDICIG GTEDTICMLE GEMKEISEAE
210 220 230 240 250
MLDAIKFGHD AIKKICALQR ELAAEVAKPK RPFSPTVAPD ELVNFVEEHC
260 270 280 290 300
SAELKALAYT PLAKEERAEK TKAIYTQTIR KTLTHFTDRV GPDQIEADPT
310 320 330 340 350
SAFCLNEHMI EECIHAVEKK VMRHMILDDG KRLDGRTLEQ VRPISIELGL
360 370 380 390 400
IPRAHGSALF TRGETQALVT LTLGTKKDAQ SVDTLTDDKD KRFMLHYNFP
410 420 430 440 450
PFSVGEIGRV GGAGRREIGH GNLAERAIKM VMPSEQEFPY TVRLVSDILE
460 470 480 490 500
SNGSSSMASV CGGTLAAMDG GIPLKKPVSG IAMGLIKEGD RYAVLSDILG
510 520 530 540 550
NEDHLGDMDF KVAGTRDGIT ACQMDIKIDG LDYHILETAL EQARKGRLHI
560 570 580 590 600
LDVMAEAIPE SRADIGKYAP RLTTIQIPVD AIGMVIGKGG ETIRSITEET
610 620 630 640 650
GAEINIDDDG TVTIACSSPE ATKAAVETIK TLVSKPEVGT IYMGKVRDIR
660 670 680 690 700
DELGAFVEFL PKTDGLVHIS EIARERIAKV SDVLKVGDRI KVKLIDVRKD
710 720 730
PRTGKTKFAL SIKALLDTDQ QAETNGEAKP ARD
Length:733
Mass (Da):79,938
Last modified:October 1, 2002 - v1
Checksum:i3C5D0C71E00C6AD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72874.1
RefSeqiNP_662532.1, NC_002932.3
WP_010933313.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72874; AAM72874; CT1649
GeneIDi1006135
KEGGicte:CT1649
PATRICifig|194439.7.peg.1491

Similar proteinsi

Entry informationi

Entry nameiPNP_CHLTE
AccessioniPrimary (citable) accession number: Q8KBY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health