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Q8KBY2

- SYL_CHLTE

UniProt

Q8KBY2 - SYL_CHLTE

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-1689-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CT1650
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Leucine--tRNA ligasePRO_0000151999Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1650.

Structurei

3D structure databases

ProteinModelPortaliQ8KBY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KBY2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYDFSALEK KWQSRWADEQ TFASSADQEK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTATDI MARYKRCQGH NVLHPMGWDA FGLPAEQFAI KTGTHPRLTT
110 120 130 140 150
EKNVASFRET LKSMGFSYDW SREINTTDPN YFKWTQWIFL KLYEKGLAYI
160 170 180 190 200
SEVDVNWCEE LKVVLANEEV DEKIADGYTV VRRPLRQWVL KITAYAERLL
210 220 230 240 250
KDLDEVDWPE NVKQMQRNWI GRSEGMEIDF ELRCHRTNLR VYTTRPDTLF
260 270 280 290 300
GATYLVISPE HPMAEKLAIA QQLVAVKKYI EQAKLKTELE RTGLQKEKTG
310 320 330 340 350
VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF
360 370 380 390 400
GLPIREVIKS PHDVQERVFD GKESVCVNSA NDEISINGLD FKTAFDRMAA
410 420 430 440 450
WLESKGKGKR KVNYKLRDWV FSRQRYWGEP IPIKHYEDGT MRPETNLPLT
460 470 480 490 500
LPEVEAYQPT STGESPLANI ESWLYGEDEH GKFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPQNSD ALVDPSLEQY WMNVDLYIGG AEHAVLHLLY SRFWHKVLYD
560 570 580 590 600
LGVVSTKEPF QRLFNQGMIL GEDNEKMSKS RGNVIPADHV LSTYGADALR
610 620 630 640 650
LYEMFLGPLD QVKPWNTHGI EGISRFLNKV WRLVWDENTE TQKTTEDKPS
660 670 680 690 700
EAILKRMHKA IKKVTEDTEQ LKFNTAISEM MVLVNELHKA GCYSRETTET
710 720 730 740 750
LLVLLSPFAP HITEELWQAL GHAESISGAV WPVFDAKLAT DDVLTIAVQV
760 770 780 790 800
NGKLRGTFEA PAGCTKEEMI ESAKKVESVA KFLDGQQIVK EIAVPGKLVN

FAVKPQQ
Length:807
Mass (Da):92,478
Last modified:October 1, 2002 - v1
Checksum:i24F1202D3C5B9205
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72875.1.
RefSeqiNP_662533.1. NC_002932.3.
WP_010933314.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM72875; AAM72875; CT1650.
GeneIDi1006136.
KEGGicte:CT1650.
PATRICi21401175. VBIChlTep116050_1492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM72875.1 .
RefSeqi NP_662533.1. NC_002932.3.
WP_010933314.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KBY2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT1650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM72875 ; AAM72875 ; CT1650 .
GeneIDi 1006136.
KEGGi cte:CT1650.
PATRICi 21401175. VBIChlTep116050_1492.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CTEP194439:GHN0-1689-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiSYL_CHLTE
AccessioniPrimary (citable) accession number: Q8KBY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3