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Q8KBY2 (SYL_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:CT1650
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length807 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 807807Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000151999

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif576 – 5805"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5791ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KBY2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 24F1202D3C5B9205

FASTA80792,478
        10         20         30         40         50         60 
MKYDFSALEK KWQSRWADEQ TFASSADQEK PKYYVLDMFP YPSGSGLHVG HLEGYTATDI 

        70         80         90        100        110        120 
MARYKRCQGH NVLHPMGWDA FGLPAEQFAI KTGTHPRLTT EKNVASFRET LKSMGFSYDW 

       130        140        150        160        170        180 
SREINTTDPN YFKWTQWIFL KLYEKGLAYI SEVDVNWCEE LKVVLANEEV DEKIADGYTV 

       190        200        210        220        230        240 
VRRPLRQWVL KITAYAERLL KDLDEVDWPE NVKQMQRNWI GRSEGMEIDF ELRCHRTNLR 

       250        260        270        280        290        300 
VYTTRPDTLF GATYLVISPE HPMAEKLAIA QQLVAVKKYI EQAKLKTELE RTGLQKEKTG 

       310        320        330        340        350        360 
VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF GLPIREVIKS 

       370        380        390        400        410        420 
PHDVQERVFD GKESVCVNSA NDEISINGLD FKTAFDRMAA WLESKGKGKR KVNYKLRDWV 

       430        440        450        460        470        480 
FSRQRYWGEP IPIKHYEDGT MRPETNLPLT LPEVEAYQPT STGESPLANI ESWLYGEDEH 

       490        500        510        520        530        540 
GKFRRETNTM PQWAGSCWYY LRFIDPQNSD ALVDPSLEQY WMNVDLYIGG AEHAVLHLLY 

       550        560        570        580        590        600 
SRFWHKVLYD LGVVSTKEPF QRLFNQGMIL GEDNEKMSKS RGNVIPADHV LSTYGADALR 

       610        620        630        640        650        660 
LYEMFLGPLD QVKPWNTHGI EGISRFLNKV WRLVWDENTE TQKTTEDKPS EAILKRMHKA 

       670        680        690        700        710        720 
IKKVTEDTEQ LKFNTAISEM MVLVNELHKA GCYSRETTET LLVLLSPFAP HITEELWQAL 

       730        740        750        760        770        780 
GHAESISGAV WPVFDAKLAT DDVLTIAVQV NGKLRGTFEA PAGCTKEEMI ESAKKVESVA 

       790        800 
KFLDGQQIVK EIAVPGKLVN FAVKPQQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM72875.1.
RefSeqNP_662533.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KBY2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT1650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM72875; AAM72875; CT1650.
GeneID1006136.
KEGGcte:CT1650.
PATRIC21401175. VBIChlTep116050_1492.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-1689-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_CHLTE
AccessionPrimary (citable) accession number: Q8KBY2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries