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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-1689-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CT1650
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519991 – 807Leucine--tRNA ligaseAdd BLAST807

Proteomic databases

PRIDEiQ8KBY2

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1650

Structurei

3D structure databases

ProteinModelPortaliQ8KBY2
SMRiQ8KBY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KBY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFSALEK KWQSRWADEQ TFASSADQEK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTATDI MARYKRCQGH NVLHPMGWDA FGLPAEQFAI KTGTHPRLTT
110 120 130 140 150
EKNVASFRET LKSMGFSYDW SREINTTDPN YFKWTQWIFL KLYEKGLAYI
160 170 180 190 200
SEVDVNWCEE LKVVLANEEV DEKIADGYTV VRRPLRQWVL KITAYAERLL
210 220 230 240 250
KDLDEVDWPE NVKQMQRNWI GRSEGMEIDF ELRCHRTNLR VYTTRPDTLF
260 270 280 290 300
GATYLVISPE HPMAEKLAIA QQLVAVKKYI EQAKLKTELE RTGLQKEKTG
310 320 330 340 350
VFTGSYAINP ANGEALPVWI SDFVLTSYGT GAIMSVPAHD SRDWEFAKKF
360 370 380 390 400
GLPIREVIKS PHDVQERVFD GKESVCVNSA NDEISINGLD FKTAFDRMAA
410 420 430 440 450
WLESKGKGKR KVNYKLRDWV FSRQRYWGEP IPIKHYEDGT MRPETNLPLT
460 470 480 490 500
LPEVEAYQPT STGESPLANI ESWLYGEDEH GKFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPQNSD ALVDPSLEQY WMNVDLYIGG AEHAVLHLLY SRFWHKVLYD
560 570 580 590 600
LGVVSTKEPF QRLFNQGMIL GEDNEKMSKS RGNVIPADHV LSTYGADALR
610 620 630 640 650
LYEMFLGPLD QVKPWNTHGI EGISRFLNKV WRLVWDENTE TQKTTEDKPS
660 670 680 690 700
EAILKRMHKA IKKVTEDTEQ LKFNTAISEM MVLVNELHKA GCYSRETTET
710 720 730 740 750
LLVLLSPFAP HITEELWQAL GHAESISGAV WPVFDAKLAT DDVLTIAVQV
760 770 780 790 800
NGKLRGTFEA PAGCTKEEMI ESAKKVESVA KFLDGQQIVK EIAVPGKLVN

FAVKPQQ
Length:807
Mass (Da):92,478
Last modified:October 1, 2002 - v1
Checksum:i24F1202D3C5B9205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72875.1
RefSeqiNP_662533.1, NC_002932.3
WP_010933314.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72875; AAM72875; CT1650
GeneIDi1006136
KEGGicte:CT1650
PATRICifig|194439.7.peg.1492

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLTE
AccessioniPrimary (citable) accession number: Q8KBY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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