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Q8KBV8 (PUR2_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:CT1674
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151442

Regions

Domain110 – 317208ATP-grasp
Nucleotide binding137 – 19862ATP By similarity

Sites

Metal binding2871Magnesium or manganese By similarity
Metal binding2891Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KBV8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8C6228E97721FA1C

FASTA42545,064
        10         20         30         40         50         60 
MKVLIIGSGA REHAMAWAVA RSSKVSTVFV APGNGGTATM GGKVRNTPVK ATDIDALLEL 

        70         80         90        100        110        120 
VAKESIGLTV VGPEQPLEAG IVNRFREAGF KVVGPTAEAA QLETSKVFAK EFMKRHGIPT 

       130        140        150        160        170        180 
AGYEVFRDYA SAKAFLETCP TFPQVIKASG LCAGKGVVVA MSRDEALEAI HEFFESRIFG 

       190        200        210        220        230        240 
DAADEVVIEA FLSGQEASVF ALTDGQNYQL FLSAQDHKRI GEGDTGKNTG GMGAYAPAPL 

       250        260        270        280        290        300 
VTPEVMRRVE EEVIRPTLAG MRADGYAYTG FLYVGLMIDK GVPSVVEYNA RLGDPETQVV 

       310        320        330        340        350        360 
LPMLKSDLFD ALLASVEGGL EVVPFEMQEG AAATVVMASA GYPDAYETGK VITIDPTVND 

       370        380        390        400        410        420 
MEGVLVFHAG TRRDGDALVT SGGRVLSVTA CAGSLKEALD RVYRAVDAIE FEGAYCRRDI 


GAKAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM72899.1.
RefSeqNP_662557.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KBV8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT1674.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM72899; AAM72899; CT1674.
GeneID1006158.
KEGGcte:CT1674.
PATRIC21401215. VBIChlTep116050_1512.

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAYKGFLYA.
OrthoDBEOG69SKD1.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-1713-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_CHLTE
AccessionPrimary (citable) accession number: Q8KBV8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways