Reviewed, UniProtKB/Swiss-Prot Q8KBJ9 (GCST_CHLTE)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	CT1788

Organism

Chlorobium tepidum [Complete proteome] [HAMAP]

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_0000122551

Sequences

	Sequence		Length	Mass (Da)
	Q8KBJ9-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5B627C302FF7C86A	FASTA	365	40,139
	10 20 30 40 50 60 MKKTALSAWH EAAGAKMIDF GGFLMPVQYT GIIAEHKAVR EAAGLFDVSH MGNFYVRGAR 70 80 90 100 110 120 ALEFLQYMTT NDLAKIVDGQ AQYTLMLYPD GGIVDDLIIY RVSADTFFLI VNASNCEKDF 130 140 150 160 170 180 DWLSSHIGQF EGVALENHTS ELSLIALQGP KSFDILARVF PGAGIDKLGS FHFIKLPFEG 190 200 210 220 230 240 AEIMVARTGY TGEAGVEICL PNERAVALWS ALMEAGKSDG IQPIGLGARD TLRLEMGYSL 250 260 270 280 290 300 YGHEIERDVN PLEARLKWVV KLNKPNFIGK QACEQVEINP RKSVVGFSLE GRAIPRQHFK 310 320 330 340 350 360 VYNSDKQEIG EVCSGTVSPT LQEPIGTASL LLDYAQPGTP IFVEIRGTMQ PGAVRRLPFV HADRP

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006470 Genomic DNA. Translation: AAM73009.1.
RefSeq	NP_662667.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1008275.
GenomeReviews	Gene locus CT1788 in contig AE006470_GR.
KEGG	cte:CT1788.
NMPDR	fig|194439.1.peg.1761.
TIGR	CT1788.
Phylogenomic databases
HOGENOM	Q8KBJ9.
OMA	VEIRGKW.
Enzyme and pathway databases
BioCyc	CTEP194439:CT_1788-MON.
BRENDA	2.1.2.10. 189605.
Family and domain databases
HAMAP	MF_00259. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CHLTE

Accession

Primary (citable) accession number: Q8KBJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)