ID   AROE_CHLTE              Reviewed;         295 AA.
AC   Q8KBH8;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=CT1809;
OS   Chlorobium tepidum.
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobaculum.
OX   NCBI_TaxID=1097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49652 / DSM 12025 / TLS;
RX   MEDLINE=22103685; PubMed=12093901; DOI=10.1073/pnas.132181499;
RA   Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M.,
RA   Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F.,
RA   Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P.,
RA   Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B.,
RA   Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M.,
RA   Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
RT   "The complete genome sequence of Chlorobium tepidum TLS, a
RT   photosynthetic, anaerobic, green-sulfur bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE006470; AAM73030.1; -; Genomic_DNA.
DR   RefSeq; NP_662688.1; -.
DR   HSSP; Q58484; 1NVT.
DR   GeneID; 1008183; -.
DR   GenomeReviews; AE006470_GR; CT1809.
DR   KEGG; cte:CT1809; -.
DR   NMPDR; fig|194439.1.peg.1782; -.
DR   TIGR; CT1809; -.
DR   HOGENOM; Q8KBH8; -.
DR   OMA; Q8KBH8; VYTIFNI.
DR   BioCyc; CTEP194439:CT_1809-MON; -.
DR   BRENDA; 1.1.1.25; 189605.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    295       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135999.
FT   NP_BIND     132    136       NADP (By similarity).
FT   ACT_SITE     72     72       Proton acceptor (Potential).
SQ   SEQUENCE   295 AA;  31734 MW;  B0A86744C10FAEA1 CRC64;
     MSNSQSKKIF GLIGKHVDYS WSPLIHNTGF EALGLPCVYT IFNIPSPEMI GDALKGSRAL
     GIAGFSVTIP YKKTVVPFLD ELSPEALSIG AVNTIVNDNG RLLGYNTDID GFAAPLLPMA
     ESIRNRPVCI FGNGGAALAA VEAFRLRFNP SSVLLVVRDT QKAEDMLEEY AYRDLVTIHA
     GREIDQPACS KLIRDCRVLV NATPVGTAGR NDHIHSILPT GHGLLHDGQI VYDMVYNPPE
     TPLLAEARAA GATVIAGIEM LIAQAARAFS IWTGQELPVD LVRKTVLAAI EKSEG
//