Reviewed, UniProtKB/Swiss-Prot Q8KBH8 (AROE_CHLTE)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	CT1809

Organism

Chlorobium tepidum [Complete proteome] [HAMAP]

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000135999
Regions
	Nucleotide binding	132 – 136	5	NADP By similarity
Sites
	Active site	72	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8KBH8-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: B0A86744C10FAEA1	FASTA	295	31,734
	10 20 30 40 50 60 MSNSQSKKIF GLIGKHVDYS WSPLIHNTGF EALGLPCVYT IFNIPSPEMI GDALKGSRAL 70 80 90 100 110 120 GIAGFSVTIP YKKTVVPFLD ELSPEALSIG AVNTIVNDNG RLLGYNTDID GFAAPLLPMA 130 140 150 160 170 180 ESIRNRPVCI FGNGGAALAA VEAFRLRFNP SSVLLVVRDT QKAEDMLEEY AYRDLVTIHA 190 200 210 220 230 240 GREIDQPACS KLIRDCRVLV NATPVGTAGR NDHIHSILPT GHGLLHDGQI VYDMVYNPPE 250 260 270 280 290 TPLLAEARAA GATVIAGIEM LIAQAARAFS IWTGQELPVD LVRKTVLAAI EKSEG

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006470 Genomic DNA. Translation: AAM73030.1.
RefSeq	NP_662688.1.
3D structure databases
HSSP	HSSP built from PDB template 1NVT based on UniProtKB Q58484.
ModBase	Search...
Genome annotation databases
GeneID	1008183.
GenomeReviews	Gene locus CT1809 in contig AE006470_GR.
KEGG	cte:CT1809.
NMPDR	fig|194439.1.peg.1782.
TIGR	CT1809.
Phylogenomic databases
HOGENOM	Q8KBH8.
OMA	Q8KBH8. VYTIFNI.
Enzyme and pathway databases
BioCyc	CTEP194439:CT_1809-MON.
BRENDA	1.1.1.25. 189605.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CHLTE

Accession

Primary (citable) accession number: Q8KBH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)