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Protein

Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotationSAAS annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotationSAAS annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processMenaquinone biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00900.

Protein family/group databases

ESTHERichlte-MENH. MenH_SHCHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotationImported
Ordered Locus Names:CT1845Imported
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)Imported
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi194439.CT1845.

Structurei

3D structure databases

ProteinModelPortaliQ8KBE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 255AB hydrolase-1InterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107J5P. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000028072.
KOiK08680.
OMAiLNDWYQQ.
OrthoDBiPOG091H05R7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
PfamiView protein in Pfam
PF12697. Abhydrolase_6. 1 hit.
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR03695. menH_SHCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KBE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTISLHLTT VGDPALPKIV FLHGFLGSGS DWLSFARKLE NRFCSILVDL
60 70 80 90 100
PGHGEAGIPA DGDPKLFFMQ TVEALKSNIR RLRAEPCVLV GYSMGGRIGL
110 120 130 140 150
ALALLYPELF SKAIIVSSSP GLQTDEKRAS RRKSDEGIAR KIERNFEGFI
160 170 180 190 200
GFWYDQPLFS TLKSHSLFRE VEAQRKQGTP QNLARALRLL GTGNQPSFWD
210 220 230 240 250
KLPGNRLPML FCVGEKDAKY VDIAKQVVEL CPSSSLELFE HCGHTLHIEE
260 270
PERFLASVER FIETHPHNSI SHDDL
Length:275
Mass (Da):30,730
Last modified:October 1, 2002 - v1
Checksum:i4F500678EDC54111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM73065.1.
RefSeqiNP_662723.1. NC_002932.3.
WP_010933504.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM73065; AAM73065; CT1845.
GeneIDi1008051.
KEGGicte:CT1845.
PATRICifig|194439.7.peg.1674.

Similar proteinsi

Entry informationi

Entry nameiQ8KBE3_CHLTE
AccessioniPrimary (citable) accession number: Q8KBE3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported