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Q8KB10

- HIS1_CHLTE

UniProt

Q8KB10 - HIS1_CHLTE

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Feedback inhibited by histidine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTEP194439:GHN0-2028-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
    Short name:
    ATP-PRTUniRule annotation
    Short name:
    ATP-PRTaseUniRule annotation
    Gene namesi
    Name:hisGUniRule annotation
    Ordered Locus Names:CT1988
    OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
    Taxonomic identifieri194439 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
    ProteomesiUP000001007: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293ATP phosphoribosyltransferasePRO_0000151843Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi194439.CT1988.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KB10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0040.
    HOGENOMiHOG000223250.
    KOiK00765.
    OMAiVMELGFG.
    OrthoDBiEOG66MQT3.

    Family and domain databases

    Gene3Di3.30.70.120. 1 hit.
    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54913. SSF54913. 1 hit.
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8KB10-1 [UniParc]FASTAAdd to Basket

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    MSNNKVLKLG LPKGSLQDST LELFANAGFH FSVQSRSYFP SIDDDELEAI    50
    LIRAQEMGRY VSLGAFDAGL TGKDWIIETD ADVVEVADLV YSKASMRPVR 100
    WVLAVPESSP IKTVKDLEGK HIATEVVNIT KKYLAENGVN ASVEFSWGAT 150
    EVKPPELADA IVEVTETGSS LRANKLRIVE TVLQSNTQLI ANKAAWADPW 200
    KRKKIENMAM LLQGAINAQG KVGLKMNAPK AALDKIMSGI PALRQPTVSD 250
    LADKEWVALE VIVSEKIVRT LIPELKRAGA EGIFEYNINK LID 293
    Length:293
    Mass (Da):32,103
    Last modified:October 1, 2002 - v1
    Checksum:i8E0EBA31FAB20ABE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM73206.1.
    RefSeqiNP_662864.1. NC_002932.3.

    Genome annotation databases

    EnsemblBacteriaiAAM73206; AAM73206; CT1988.
    GeneIDi1007573.
    KEGGicte:CT1988.
    PATRICi21401795. VBIChlTep116050_1801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM73206.1 .
    RefSeqi NP_662864.1. NC_002932.3.

    3D structure databases

    ProteinModelPortali Q8KB10.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 194439.CT1988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM73206 ; AAM73206 ; CT1988 .
    GeneIDi 1007573.
    KEGGi cte:CT1988.
    PATRICi 21401795. VBIChlTep116050_1801.

    Phylogenomic databases

    eggNOGi COG0040.
    HOGENOMi HOG000223250.
    KOi K00765.
    OMAi VMELGFG.
    OrthoDBi EOG66MQT3.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci CTEP194439:GHN0-2028-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.120. 1 hit.
    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54913. SSF54913. 1 hit.
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49652 / DSM 12025 / TLS.

    Entry informationi

    Entry nameiHIS1_CHLTE
    AccessioniPrimary (citable) accession number: Q8KB10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3