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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-2028-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:CT1988
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293ATP phosphoribosyltransferasePRO_0000151843Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1988.

Structurei

3D structure databases

ProteinModelPortaliQ8KB10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223250.
KOiK00765.
OMAiCDIVSSG.
OrthoDBiEOG66MQT3.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KB10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNKVLKLG LPKGSLQDST LELFANAGFH FSVQSRSYFP SIDDDELEAI
60 70 80 90 100
LIRAQEMGRY VSLGAFDAGL TGKDWIIETD ADVVEVADLV YSKASMRPVR
110 120 130 140 150
WVLAVPESSP IKTVKDLEGK HIATEVVNIT KKYLAENGVN ASVEFSWGAT
160 170 180 190 200
EVKPPELADA IVEVTETGSS LRANKLRIVE TVLQSNTQLI ANKAAWADPW
210 220 230 240 250
KRKKIENMAM LLQGAINAQG KVGLKMNAPK AALDKIMSGI PALRQPTVSD
260 270 280 290
LADKEWVALE VIVSEKIVRT LIPELKRAGA EGIFEYNINK LID
Length:293
Mass (Da):32,103
Last modified:October 1, 2002 - v1
Checksum:i8E0EBA31FAB20ABE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM73206.1.
RefSeqiNP_662864.1. NC_002932.3.
WP_010933644.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM73206; AAM73206; CT1988.
GeneIDi1007573.
KEGGicte:CT1988.
PATRICi21401795. VBIChlTep116050_1801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM73206.1.
RefSeqiNP_662864.1. NC_002932.3.
WP_010933644.1. NC_002932.3.

3D structure databases

ProteinModelPortaliQ8KB10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi194439.CT1988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM73206; AAM73206; CT1988.
GeneIDi1007573.
KEGGicte:CT1988.
PATRICi21401795. VBIChlTep116050_1801.

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223250.
KOiK00765.
OMAiCDIVSSG.
OrthoDBiEOG66MQT3.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.
BioCyciCTEP194439:GHN0-2028-MONOMER.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / NBRC 103806 / TLS.

Entry informationi

Entry nameiHIS1_CHLTE
AccessioniPrimary (citable) accession number: Q8KB10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.