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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. no protein annotated in this organism
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-2028-MONOMER
UniPathwayiUPA00031; UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:CT1988
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001518431 – 293ATP phosphoribosyltransferaseAdd BLAST293

Proteomic databases

PRIDEiQ8KB10

Interactioni

Protein-protein interaction databases

STRINGi194439.CT1988

Structurei

3D structure databases

ProteinModelPortaliQ8KB10
SMRiQ8KB10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E21 Bacteria
COG0040 LUCA
HOGENOMiHOG000223250
KOiK00765
OMAiYVMMDYD
OrthoDBiPOG091H05D7

Family and domain databases

Gene3Di3.30.70.120, 1 hit
HAMAPiMF_00079 HisG_Long, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR001348 ATP_PRibTrfase_HisG
IPR020621 ATP_PRibTrfase_HisG_long
IPR013115 HisG_C
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
PF08029 HisG_C, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
TIGR03455 HisG_C-term, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KB10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNKVLKLG LPKGSLQDST LELFANAGFH FSVQSRSYFP SIDDDELEAI
60 70 80 90 100
LIRAQEMGRY VSLGAFDAGL TGKDWIIETD ADVVEVADLV YSKASMRPVR
110 120 130 140 150
WVLAVPESSP IKTVKDLEGK HIATEVVNIT KKYLAENGVN ASVEFSWGAT
160 170 180 190 200
EVKPPELADA IVEVTETGSS LRANKLRIVE TVLQSNTQLI ANKAAWADPW
210 220 230 240 250
KRKKIENMAM LLQGAINAQG KVGLKMNAPK AALDKIMSGI PALRQPTVSD
260 270 280 290
LADKEWVALE VIVSEKIVRT LIPELKRAGA EGIFEYNINK LID
Length:293
Mass (Da):32,103
Last modified:October 1, 2002 - v1
Checksum:i8E0EBA31FAB20ABE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM73206.1
RefSeqiNP_662864.1, NC_002932.3
WP_010933644.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM73206; AAM73206; CT1988
GeneIDi1007573
KEGGicte:CT1988
PATRICifig|194439.7.peg.1801

Similar proteinsi

Entry informationi

Entry nameiHIS1_CHLTE
AccessioniPrimary (citable) accession number: Q8KB10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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