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Q8KAX9

- DAPF_CHLTE

UniProt

Q8KAX9 - DAPF_CHLTE

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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei6 – 61SubstrateUniRule annotation
Binding sitei39 – 391SubstrateUniRule annotation
Binding sitei57 – 571SubstrateUniRule annotation
Active sitei66 – 661Proton donor/acceptorUniRule annotation
Sitei138 – 1381Important for catalytic activityUniRule annotation
Binding sitei170 – 1701SubstrateUniRule annotation
Sitei188 – 1881Important for catalytic activityUniRule annotation
Active sitei198 – 1981Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-2061-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:CT2021
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Diaminopimelate epimerasePRO_0000149832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 198

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi194439.CT2021.

Structurei

3D structure databases

ProteinModelPortaliQ8KAX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 683Substrate bindingUniRule annotation
Regioni188 – 1892Substrate bindingUniRule annotation
Regioni199 – 2002Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KAX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGAGNDFIV IDNRQGLFNL THEQVRAMCT RRTGIGADGL ILLETSETAD
60 70 80 90 100
FRMNYHNADG FPGTMCGNGG RCAVWFAHLI GIRPTGKHYR FEAGPSTYEA
110 120 130 140 150
EVTGEESVRL HMLPPSDFRD GLQAGAWNCH FVDTGSPHAI AYVNNLDQLD
160 170 180 190 200
VLTEGGNIRH NKELFPDGTN VNFLEITAPD ALSIRTFERG VEDETLACGT
210 220 230 240 250
GTVAAALMSF RLGKVTSSLV RVKVKSGETL MVGFNEMMDE IYLEGPARAV

YRGTITL
Length:257
Mass (Da):28,053
Last modified:October 1, 2002 - v1
Checksum:iA25BD74CE3A5E9A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM73238.1.
RefSeqiNP_662896.1. NC_002932.3.
WP_010933676.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM73238; AAM73238; CT2021.
GeneIDi1007540.
KEGGicte:CT2021.
PATRICi21401855. VBIChlTep116050_1831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM73238.1 .
RefSeqi NP_662896.1. NC_002932.3.
WP_010933676.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KAX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT2021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM73238 ; AAM73238 ; CT2021 .
GeneIDi 1007540.
KEGGi cte:CT2021.
PATRICi 21401855. VBIChlTep116050_1831.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi LIVEPPY.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci CTEP194439:GHN0-2061-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiDAPF_CHLTE
AccessioniPrimary (citable) accession number: Q8KAX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3