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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayi: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processChlorophyll biosynthesis, Porphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-2140-MONOMER
UniPathwayiUPA00251; UER00317
UPA00668

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CT2099
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002435621 – 431Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8KAQ7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT2099

Structurei

3D structure databases

ProteinModelPortaliQ8KAQ7
SMRiQ8KAQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KAQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLTRSAEL FEKAKKFIPG GVNSPVRAFK SVGGTPIYMA KGQGAYMTDV
60 70 80 90 100
DGNTYLDYVG SWGPFILGSM HPRVTAAIEY TLRNIGTSFG TPIELEIEIA
110 120 130 140 150
ELLCKIVPSL EMVRMVNSGT EATMSAVRLA RGYTGKDKII KFEGCYHGHG
160 170 180 190 200
DSFLIKAGSG VLTLGDPDSP GVTKGTANDT LNATYNDIES VKAIVNENKG
210 220 230 240 250
QVAAIIIEPV AGNTGVIPAK KEFLVALREL CDAEGIVLIF DEVMCGFRVA
260 270 280 290 300
LGGAQELYGV TPDLTTMGKI IGGGLPVGAF GGKRHIMENI APLGSVYQAG
310 320 330 340 350
TLSGNPLALT AGLETLKILM EENPYPELER KAAFLEAGFK ANMEKLGLNY
360 370 380 390 400
TQNRVGSMAC LFFTETPVVD YKSAITADTA KYGKYFHSML DQGIYLAPSQ
410 420 430
FEAMFTSFAH TDEDLEKTVK ANYNALVAAT K
Length:431
Mass (Da):46,183
Last modified:October 1, 2002 - v1
Checksum:iDA53B9BF9BA88EA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM73315.1
RefSeqiNP_662973.1, NC_002932.3
WP_010933753.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM73315; AAM73315; CT2099
GeneIDi1007463
KEGGicte:CT2099
PATRICifig|194439.7.peg.1903

Similar proteinsi

Entry informationi

Entry nameiGSA_CHLTE
AccessioniPrimary (citable) accession number: Q8KAQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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