Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8KAN7 (RNC_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:CT2119
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180388

Regions

Domain31 – 162132RNase III
Domain189 – 25870DRBM

Sites

Active site791 Potential
Active site1511 By similarity
Metal binding751Magnesium By similarity
Metal binding1481Magnesium By similarity
Metal binding1511Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KAN7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FCCBAE32DB324DCD

FASTA27229,984
        10         20         30         40         50         60 
MSLQFLRSEA SDGAGETSDA SSADFLLDPQ TATHLARLTG RPCNRLIYRT ALTHRSVLHD 

        70         80         90        100        110        120 
HHSEEHKPES NQRLEFLGDA VLDLLISEHL FKQFPGSDEG HLSSNRAKIV NRKSLAAFAL 

       130        140        150        160        170        180 
ELQLGEHLII GESADKQKIR TSESALADAL EALVGAIYLD QGLAGAERFI TNHVIAKVDL 

       190        200        210        220        230        240 
HKLVEAEYNY KSRLIEYTQS RQLPPPLYTV ITEEGAEHEK TFVVEVSCNG QPLGRGTAPR 

       250        260        270 
KKDAEQLAAK EAMKRLESGD LGNLNEPSPQ NS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM73335.1.
RefSeqNP_662993.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KAN7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT2119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM73335; AAM73335; CT2119.
GeneID1007442.
KEGGcte:CT2119.
PATRIC21402037. VBIChlTep116050_1920.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMAAQKDPKT.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-2161-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_CHLTE
AccessionPrimary (citable) accession number: Q8KAN7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families