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Protein

Ribonuclease 3

Gene

rnc

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75MagnesiumUniRule annotation1
Active sitei79UniRule annotation1
Metal bindingi148MagnesiumUniRule annotation1
Active sitei151UniRule annotation1
Metal bindingi151MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-2161-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:CT2119
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803881 – 272Ribonuclease 3Add BLAST272

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT2119

Structurei

3D structure databases

ProteinModelPortaliQ8KAN7
SMRiQ8KAN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 162RNase IIIUniRule annotationAdd BLAST132
Domaini189 – 258DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KAN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQFLRSEA SDGAGETSDA SSADFLLDPQ TATHLARLTG RPCNRLIYRT
60 70 80 90 100
ALTHRSVLHD HHSEEHKPES NQRLEFLGDA VLDLLISEHL FKQFPGSDEG
110 120 130 140 150
HLSSNRAKIV NRKSLAAFAL ELQLGEHLII GESADKQKIR TSESALADAL
160 170 180 190 200
EALVGAIYLD QGLAGAERFI TNHVIAKVDL HKLVEAEYNY KSRLIEYTQS
210 220 230 240 250
RQLPPPLYTV ITEEGAEHEK TFVVEVSCNG QPLGRGTAPR KKDAEQLAAK
260 270
EAMKRLESGD LGNLNEPSPQ NS
Length:272
Mass (Da):29,984
Last modified:October 1, 2002 - v1
Checksum:iFCCBAE32DB324DCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM73335.1
RefSeqiNP_662993.1, NC_002932.3
WP_010933773.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM73335; AAM73335; CT2119
GeneIDi1007442
KEGGicte:CT2119
PATRICifig|194439.7.peg.1920

Similar proteinsi

Entry informationi

Entry nameiRNC_CHLTE
AccessioniPrimary (citable) accession number: Q8KAN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health