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Q8KAN3 (GCSPB_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Synonyms:gcvP2
Ordered Locus Names:CT2123
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167003

Amino acid modifications

Modified residue2691N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KAN3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 278E12554383E2C2

FASTA48653,810
        10         20         30         40         50         60 
MKEQLIFDLS RSGRKGYSLS PLDIPERPAD ELLPSKFLRK EPAELPEMAE SEVVRHFIRL 

        70         80         90        100        110        120 
SNLNYHVDKN MYPLGSCTMK YNPKINDYTC DLPGFASMHP LQPESTSQGA LQLMYELAEM 

       130        140        150        160        170        180 
LKEIAGMKAV TLQPAAGAHG ELTGILLIKK YHEKLGNKRH KLLVVDSAHG TNPASAALGG 

       190        200        210        220        230        240 
YECVSVKCDE SGCTDMGDLR AKLDGEVAAL MLTNPNTVGI FEKQIPEIEK LVHGNGSLLY 

       250        260        270        280        290        300 
MDGANMNALL GITRPGDMGF DVMHYNLHKT FSAPHGGGGP GSGPVGVSER LVEFLPVPVI 

       310        320        330        340        350        360 
EKFEKDGQTR YRLNSSKPNT IGRMMNFYGN FSVLVRAYTY IRMLGADGLR RVSENAIINA 

       370        380        390        400        410        420 
NYLLQRLVEH YALPYPRPVM HEFCLSGDRQ KKEHGVRTLD IAKRLLDYGY HAPTVYFPLI 

       430        440        450        460        470        480 
VSEALMIEPT ETEAKETLNA FADAMIAIAE EAKSNPDLIK SAPTTTPVKR LDEAQASRQL 


NICCQH 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM73339.1.
RefSeqNP_662997.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KAN3.
SMRQ8KAN3. Positions 4-485.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT2123.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM73339; AAM73339; CT2123.
GeneID1007438.
KEGGcte:CT2123.
PATRIC21402045. VBIChlTep116050_1924.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAWTGLMMI.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-2165-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_CHLTE
AccessionPrimary (citable) accession number: Q8KAN3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families