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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-2165-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Synonyms:gcvP2
Ordered Locus Names:CT2123
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670031 – 486Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8KAN3

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT2123

Structurei

3D structure databases

ProteinModelPortaliQ8KAN3
SMRiQ8KAN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KAN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEQLIFDLS RSGRKGYSLS PLDIPERPAD ELLPSKFLRK EPAELPEMAE
60 70 80 90 100
SEVVRHFIRL SNLNYHVDKN MYPLGSCTMK YNPKINDYTC DLPGFASMHP
110 120 130 140 150
LQPESTSQGA LQLMYELAEM LKEIAGMKAV TLQPAAGAHG ELTGILLIKK
160 170 180 190 200
YHEKLGNKRH KLLVVDSAHG TNPASAALGG YECVSVKCDE SGCTDMGDLR
210 220 230 240 250
AKLDGEVAAL MLTNPNTVGI FEKQIPEIEK LVHGNGSLLY MDGANMNALL
260 270 280 290 300
GITRPGDMGF DVMHYNLHKT FSAPHGGGGP GSGPVGVSER LVEFLPVPVI
310 320 330 340 350
EKFEKDGQTR YRLNSSKPNT IGRMMNFYGN FSVLVRAYTY IRMLGADGLR
360 370 380 390 400
RVSENAIINA NYLLQRLVEH YALPYPRPVM HEFCLSGDRQ KKEHGVRTLD
410 420 430 440 450
IAKRLLDYGY HAPTVYFPLI VSEALMIEPT ETEAKETLNA FADAMIAIAE
460 470 480
EAKSNPDLIK SAPTTTPVKR LDEAQASRQL NICCQH
Length:486
Mass (Da):53,810
Last modified:October 1, 2002 - v1
Checksum:i278E12554383E2C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM73339.1
RefSeqiNP_662997.1, NC_002932.3
WP_010933777.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM73339; AAM73339; CT2123
GeneIDi1007438
KEGGicte:CT2123
PATRICifig|194439.7.peg.1924

Similar proteinsi

Entry informationi

Entry nameiGCSPB_CHLTE
AccessioniPrimary (citable) accession number: Q8KAN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health