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Q8KAN3

- GCSPB_CHLTE

UniProt

Q8KAN3 - GCSPB_CHLTE

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-2165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Synonyms:gcvP2
Ordered Locus Names:CT2123
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT2123.

Structurei

3D structure databases

ProteinModelPortaliQ8KAN3.
SMRiQ8KAN3. Positions 4-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KAN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEQLIFDLS RSGRKGYSLS PLDIPERPAD ELLPSKFLRK EPAELPEMAE
60 70 80 90 100
SEVVRHFIRL SNLNYHVDKN MYPLGSCTMK YNPKINDYTC DLPGFASMHP
110 120 130 140 150
LQPESTSQGA LQLMYELAEM LKEIAGMKAV TLQPAAGAHG ELTGILLIKK
160 170 180 190 200
YHEKLGNKRH KLLVVDSAHG TNPASAALGG YECVSVKCDE SGCTDMGDLR
210 220 230 240 250
AKLDGEVAAL MLTNPNTVGI FEKQIPEIEK LVHGNGSLLY MDGANMNALL
260 270 280 290 300
GITRPGDMGF DVMHYNLHKT FSAPHGGGGP GSGPVGVSER LVEFLPVPVI
310 320 330 340 350
EKFEKDGQTR YRLNSSKPNT IGRMMNFYGN FSVLVRAYTY IRMLGADGLR
360 370 380 390 400
RVSENAIINA NYLLQRLVEH YALPYPRPVM HEFCLSGDRQ KKEHGVRTLD
410 420 430 440 450
IAKRLLDYGY HAPTVYFPLI VSEALMIEPT ETEAKETLNA FADAMIAIAE
460 470 480
EAKSNPDLIK SAPTTTPVKR LDEAQASRQL NICCQH
Length:486
Mass (Da):53,810
Last modified:October 1, 2002 - v1
Checksum:i278E12554383E2C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM73339.1.
RefSeqiNP_662997.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM73339; AAM73339; CT2123.
GeneIDi1007438.
KEGGicte:CT2123.
PATRICi21402045. VBIChlTep116050_1924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA. Translation: AAM73339.1 .
RefSeqi NP_662997.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KAN3.
SMRi Q8KAN3. Positions 4-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 194439.CT2123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM73339 ; AAM73339 ; CT2123 .
GeneIDi 1007438.
KEGGi cte:CT2123.
PATRICi 21402045. VBIChlTep116050_1924.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CTEP194439:GHN0-2165-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiGCSPB_CHLTE
AccessioniPrimary (citable) accession number: Q8KAN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3