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Q8KAD1

- PCKG_CHLTE

UniProt

Q8KAD1 - PCKG_CHLTE

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, pckA, CT2232
Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate By similarity
Binding sitei220 – 2201Substrate; via amide nitrogen By similarity
Metal bindingi227 – 2271Manganese By similarity
Binding sitei227 – 2271Substrate By similarity
Metal bindingi247 – 2471Manganese; via tele nitrogen By similarity
Binding sitei269 – 2691Substrate By similarity
Active sitei271 – 2711 By similarity
Metal bindingi296 – 2961Manganese By similarity
Binding sitei388 – 3881GTP By similarity
Binding sitei419 – 4191GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi270 – 2756GTP By similarity
Nucleotide bindingi512 – 5154GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:GHN0-2280-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Synonyms:pckA
Ordered Locus Names:CT2232
OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000001007: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103599Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi194439.CT2232.

Structurei

3D structure databases

ProteinModelPortaliQ8KAD1.
SMRiQ8KAD1. Positions 12-600.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni386 – 3883Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KAD1-1 [UniParc]FASTAAdd to Basket

« Hide

MEPIPINAPD SVRNLKLLQW VRETAELCQP DSVCWCDGSV EEYDRLCNEM    50
VASGTFIKLS EQKRPNSYLC RSDPSDVARV EDRTFICSIR RQDAGPTNNW 100
VAPKEMKATL NKLLAGCMKG RTMYIIPFSM GPLGSHIAHI GVEITDSPYV 150
VTNMRIMTRM GRAVLDLLDE EAEFVPCLHS VGAPLEPGQQ DVPWPCNDTK 200
YIVHFPEERS IVSYGSGYGG NALLGKKCFA LRIASSMARD EGWLAEHMLI 250
LGVESPEGEK DYVAAAFPSA CGKTNFAMMI PPGEMEGWKI TTVGDDIAWI 300
KQGKDGRLYA INPEYGFFGV APGTSEKSNP NAMATLHANC IFTNVALTPD 350
GDVWWEGMTD TPPDFLIDWQ GKPWVPGCER PAAHPNARFT APAHQCPVID 400
ENWENPDGVP ISAFIFGGRR GDTIPLVYQS ANWYYGVYLA ATMGSEKTAA 450
AAGKIGDVRR DPFAMLPFCG YHMGDYFNHW LHVGRTLTDP PRIFGVNWFR 500
KDENGKFLWP GFGENMRVLK WIIGRVHGRA AAVESPLGWM PRYESLDWRG 550
LDGFTRDKFS TLMSVDREAW KQELFSHEEL LEKLYDRLPK EFTHIRELML 600
STLWRSPEHW ELAPERYTAE H 621
Length:621
Mass (Da):69,933
Last modified:October 1, 2002 - v1
Checksum:i5F07BF2C8DA4C003
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM73448.1.
RefSeqiNP_663106.1. NC_002932.3.

Genome annotation databases

EnsemblBacteriaiAAM73448; AAM73448; CT2232.
GeneIDi1007328.
KEGGicte:CT2232.
PATRICi21402259. VBIChlTep116050_2025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006470 Genomic DNA. Translation: AAM73448.1 .
RefSeqi NP_663106.1. NC_002932.3.

3D structure databases

ProteinModelPortali Q8KAD1.
SMRi Q8KAD1. Positions 12-600.
ModBasei Search...

Protein-protein interaction databases

STRINGi 194439.CT2232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM73448 ; AAM73448 ; CT2232 .
GeneIDi 1007328.
KEGGi cte:CT2232.
PATRICi 21402259. VBIChlTep116050_2025.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci CTEP194439:GHN0-2280-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49652 / DSM 12025 / TLS.

Entry informationi

Entry nameiPCKG_CHLTE
AccessioniPrimary (citable) accession number: Q8KAD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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