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Q8KAD1

- PCKG_CHLTE

UniProt

Q8KAD1 - PCKG_CHLTE

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei220 – 2201Substrate; via amide nitrogenUniRule annotation
    Metal bindingi227 – 2271ManganeseUniRule annotation
    Binding sitei227 – 2271SubstrateUniRule annotation
    Metal bindingi247 – 2471Manganese; via tele nitrogenUniRule annotation
    Binding sitei269 – 2691SubstrateUniRule annotation
    Active sitei271 – 2711UniRule annotation
    Metal bindingi296 – 2961ManganeseUniRule annotation
    Binding sitei388 – 3881GTPUniRule annotation
    Binding sitei419 – 4191GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi270 – 2756GTPUniRule annotation
    Nucleotide bindingi512 – 5154GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTEP194439:GHN0-2280-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Synonyms:pckA
    Ordered Locus Names:CT2232
    OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
    Taxonomic identifieri194439 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
    ProteomesiUP000001007: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103599Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi194439.CT2232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KAD1.
    SMRiQ8KAD1. Positions 12-600.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni386 – 3883Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8KAD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPIPINAPD SVRNLKLLQW VRETAELCQP DSVCWCDGSV EEYDRLCNEM    50
    VASGTFIKLS EQKRPNSYLC RSDPSDVARV EDRTFICSIR RQDAGPTNNW 100
    VAPKEMKATL NKLLAGCMKG RTMYIIPFSM GPLGSHIAHI GVEITDSPYV 150
    VTNMRIMTRM GRAVLDLLDE EAEFVPCLHS VGAPLEPGQQ DVPWPCNDTK 200
    YIVHFPEERS IVSYGSGYGG NALLGKKCFA LRIASSMARD EGWLAEHMLI 250
    LGVESPEGEK DYVAAAFPSA CGKTNFAMMI PPGEMEGWKI TTVGDDIAWI 300
    KQGKDGRLYA INPEYGFFGV APGTSEKSNP NAMATLHANC IFTNVALTPD 350
    GDVWWEGMTD TPPDFLIDWQ GKPWVPGCER PAAHPNARFT APAHQCPVID 400
    ENWENPDGVP ISAFIFGGRR GDTIPLVYQS ANWYYGVYLA ATMGSEKTAA 450
    AAGKIGDVRR DPFAMLPFCG YHMGDYFNHW LHVGRTLTDP PRIFGVNWFR 500
    KDENGKFLWP GFGENMRVLK WIIGRVHGRA AAVESPLGWM PRYESLDWRG 550
    LDGFTRDKFS TLMSVDREAW KQELFSHEEL LEKLYDRLPK EFTHIRELML 600
    STLWRSPEHW ELAPERYTAE H 621
    Length:621
    Mass (Da):69,933
    Last modified:October 1, 2002 - v1
    Checksum:i5F07BF2C8DA4C003
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM73448.1.
    RefSeqiNP_663106.1. NC_002932.3.

    Genome annotation databases

    EnsemblBacteriaiAAM73448; AAM73448; CT2232.
    GeneIDi1007328.
    KEGGicte:CT2232.
    PATRICi21402259. VBIChlTep116050_2025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM73448.1 .
    RefSeqi NP_663106.1. NC_002932.3.

    3D structure databases

    ProteinModelPortali Q8KAD1.
    SMRi Q8KAD1. Positions 12-600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 194439.CT2232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM73448 ; AAM73448 ; CT2232 .
    GeneIDi 1007328.
    KEGGi cte:CT2232.
    PATRICi 21402259. VBIChlTep116050_2025.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci CTEP194439:GHN0-2280-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49652 / DSM 12025 / TLS.

    Entry informationi

    Entry nameiPCKG_CHLTE
    AccessioniPrimary (citable) accession number: Q8KAD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3