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Q8KA80

- EFP_BUCAP

UniProt

Q8KA80 - EFP_BUCAP

Protein

Elongation factor P

Gene

efp

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. translation elongation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-22-MONOMER.
    UniPathwayiUPA00345.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor PUniRule annotation
    Short name:
    EF-PUniRule annotation
    Gene namesi
    Name:efpUniRule annotation
    Ordered Locus Names:BUsg_021
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Elongation factor PPRO_0000094216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-(3,6-diaminohexanoyl)-5-hydroxylysineUniRule annotation

    Post-translational modificationi

    May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.UniRule annotation

    Keywords - PTMi

    Hydroxylation

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg021.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KA80.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the elongation factor P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0231.
    KOiK02356.
    OMAiGKGQAFS.
    OrthoDBiEOG6JQH6Q.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00141. EF_P.
    InterProiIPR015365. Elong-fact-P_C.
    IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR020599. Transl_elong_fac_P/YeiP.
    IPR013185. Transl_elong_KOW-like.
    IPR001059. Transl_elong_P/YeiP_cen.
    IPR013852. Transl_elong_P/YeiP_CS.
    IPR011768. Transl_elongation_fac_P.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PfamiPF01132. EFP. 1 hit.
    PF08207. EFP_N. 1 hit.
    PF09285. Elong-fact-P_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005901. EF-P. 1 hit.
    SMARTiSM00841. Elong-fact-P_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 2 hits.
    TIGRFAMsiTIGR00038. efp. 1 hit.
    PROSITEiPS01275. EFP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8KA80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVYHSNNFR SGRKIIFEKE PCLIESSEFV KPGKGQSFVR VKLRKLLTKQ    50
    LIEKTFKSTD SLEIADVSEY TLSYLYNDGH FWYFINNNFE ELSVDKKIVG 100
    VNKKWLSEQD TCVITFWNNQ AISITPNIFV ELKVIDTEIA LKSDTINTTT 150
    KLATLSTGAI LKVPLFIQIG SLIKVDTRSG EYVSRIK 187
    Length:187
    Mass (Da):21,469
    Last modified:October 1, 2002 - v1
    Checksum:i86C6C324DACF059D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67593.1.
    RefSeqiNP_660382.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67593; AAM67593; BUsg_021.
    GeneIDi1005837.
    KEGGibas:BUsg021.
    PATRICi21246799. VBIBucAph100086_0021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67593.1 .
    RefSeqi NP_660382.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8KA80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg021.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67593 ; AAM67593 ; BUsg_021 .
    GeneIDi 1005837.
    KEGGi bas:BUsg021.
    PATRICi 21246799. VBIBucAph100086_0021.

    Phylogenomic databases

    eggNOGi COG0231.
    KOi K02356.
    OMAi GKGQAFS.
    OrthoDBi EOG6JQH6Q.

    Enzyme and pathway databases

    UniPathwayi UPA00345 .
    BioCyci BAPH198804:GHMG-22-MONOMER.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00141. EF_P.
    InterProi IPR015365. Elong-fact-P_C.
    IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR020599. Transl_elong_fac_P/YeiP.
    IPR013185. Transl_elong_KOW-like.
    IPR001059. Transl_elong_P/YeiP_cen.
    IPR013852. Transl_elong_P/YeiP_CS.
    IPR011768. Transl_elongation_fac_P.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    Pfami PF01132. EFP. 1 hit.
    PF08207. EFP_N. 1 hit.
    PF09285. Elong-fact-P_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005901. EF-P. 1 hit.
    SMARTi SM00841. Elong-fact-P_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 2 hits.
    TIGRFAMsi TIGR00038. efp. 1 hit.
    PROSITEi PS01275. EFP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiEFP_BUCAP
    AccessioniPrimary (citable) accession number: Q8KA80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3