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Q8KA77 (FTSY_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal recognition particle receptor FtsY

Short name=SRP receptor
Gene names
Name:ftsY
Ordered Locus Names:BUsg_025
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components By similarity. HAMAP-Rule MF_00920

Subunit structure

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm By similarity HAMAP-Rule MF_00920.

Sequence similarities

Belongs to the GTP-binding SRP family. FtsY subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Membrane
   LigandGTP-binding
Nucleotide-binding
   Molecular functionReceptor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSRP-dependent cotranslational protein targeting to membrane

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

intrinsic component of plasma membrane

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Signal recognition particle receptor FtsY HAMAP-Rule MF_00920
PRO_0000101129

Regions

Nucleotide binding156 – 1638GTP By similarity
Nucleotide binding238 – 2425GTP By similarity
Nucleotide binding302 – 3054GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KA77 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 1CA5A59A4B6E7FF3

FASTA35139,470
        10         20         30         40         50         60 
MNFDKKNSFF SWINSKIKKN NKKEKKENIL LKKEKEGIHT IQNIDNKKID FLFKLKNSLN 

        70         80         90        100        110        120 
KTKQFFGDSI SRIFLSKKID DAFFEELEDT MLLSDIGVHT TDQIISKLIN DATHKELKNP 

       130        140        150        160        170        180 
EKVYFLLKEH MYSILNRVEK PLKISNHTPF VILVVGINGT GKTTTVSKLA KKYKLAGKSV 

       190        200        210        220        230        240 
MLAAADTFRA AGIEQLQILG KRNNIPVISQ SSGSDPASVA FDAVKSAISK KIDVLIIDTA 

       250        260        270        280        290        300 
GRLHNKLHLL EELKKMVRVI KKLNLSAPHE IMLIIDACNG QNTIKQTEMF HKAINLTGLV 

       310        320        330        340        350 
ITKLDGTAKG GVIFSLANQF LIPIRYIGIG EKTTDLVVFN SNDFIKSIFV K 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67596.1.
RefSeqNP_660385.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8KA77.
SMRQ8KA77. Positions 58-351.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg025.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67596; AAM67596; BUsg_025.
GeneID1005841.
KEGGbas:BUsg025.
PATRIC21246807. VBIBucAph100086_0025.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0552.
KOK03110.
OMASIDEIDW.
OrthoDBEOG62K1ZH.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-26-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00920. FtsY.
InterProIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00064. ftsY. 1 hit.
PROSITEPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSY_BUCAP
AccessionPrimary (citable) accession number: Q8KA77
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names