Q8KA77 (FTSY_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal recognition particle receptor FtsY
Short name=SRP receptor

Gene names

Name:	ftsY
Ordered Locus Names:	BUsg_025

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components By similarity. HAMAP-Rule MF_00920
Subunit structure	Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm By similarity HAMAP-Rule MF_00920.
Sequence similarities	Belongs to the GTP-binding SRP family. FtsY subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell intrinsic to plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Signal recognition particle receptor FtsY HAMAP-Rule MF_00920		PRO_0000101129
Regions
	Nucleotide binding	156 – 163	8	GTP By similarity
	Nucleotide binding	238 – 242	5	GTP By similarity
	Nucleotide binding	302 – 305	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8KA77 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1CA5A59A4B6E7FF3	FASTA	351	39,470
	10 20 30 40 50 60 MNFDKKNSFF SWINSKIKKN NKKEKKENIL LKKEKEGIHT IQNIDNKKID FLFKLKNSLN 70 80 90 100 110 120 KTKQFFGDSI SRIFLSKKID DAFFEELEDT MLLSDIGVHT TDQIISKLIN DATHKELKNP 130 140 150 160 170 180 EKVYFLLKEH MYSILNRVEK PLKISNHTPF VILVVGINGT GKTTTVSKLA KKYKLAGKSV 190 200 210 220 230 240 MLAAADTFRA AGIEQLQILG KRNNIPVISQ SSGSDPASVA FDAVKSAISK KIDVLIIDTA 250 260 270 280 290 300 GRLHNKLHLL EELKKMVRVI KKLNLSAPHE IMLIIDACNG QNTIKQTEMF HKAINLTGLV 310 320 330 340 350 ITKLDGTAKG GVIFSLANQF LIPIRYIGIG EKTTDLVVFN SNDFIKSIFV K

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67596.1.
RefSeq	NP_660385.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8KA77.
SMR	Q8KA77. Positions 58-351.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg025.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67596; AAM67596; BUsg_025.
GeneID	1005841.
KEGG	bas:BUsg025.
PATRIC	21246807. VBIBucAph100086_0025.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0552.
KO	K03110.
OMA	EKINDPQ.
ProtClustDB	PRK10416.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-26-MONOMER.
Family and domain databases
HAMAP	MF_00920. FtsY.
InterPro	IPR003593. AAA+_ATPase. IPR027417. P-loop_NTPase. IPR013822. Signal_recog_particl_SRP54_hlx. IPR004390. SR_rcpt_FtsY. IPR000897. SRP54_GTPase_dom. [Graphical view]
Pfam	PF00448. SRP54. 1 hit. PF02881. SRP54_N. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00962. SRP54. 1 hit. SM00963. SRP54_N. 1 hit. [Graphical view]
SUPFAM	SSF47364. SRP54. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00064. ftsY. 1 hit.
PROSITE	PS00300. SRP54. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSY_BUCAP

Accession

Primary (citable) accession number: Q8KA77

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program