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Q8KA75

- GLMS_BUCAP

UniProt

Q8KA75 - GLMS_BUCAP

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei603 – 6031For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-28-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BUsg_027
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135312Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg027.

Structurei

3D structure databases

ProteinModelPortaliQ8KA75.
SMRiQ8KA75. Positions 2-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini287 – 427141SIS 1UniRule annotationAdd
BLAST
Domaini459 – 598140SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8KA75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVAAVTQ RNIIDFLLEG IKKLEYRGYD SSGLAIINKN QNIVRIRCVG
60 70 80 90 100
RVNKLLKKVK KKKLFSNIGL AHTRWATHGQ VSEKNTHPHI SSHIAVVHNG
110 120 130 140 150
VIENNTKLRH FLEKKGYIFY SDTDTEVIAH LLHWEQTKTG ESLVEVIQRS
160 170 180 190 200
KMKLNGNYSM VVMDAYNSSR LIAVRSGSPL VIGLGIKENF IASDQIALLN
210 220 230 240 250
ITKRFIYLEE GDTAIVETKK INIFNKNNLI IKRKEITSNV KYKSINKGKY
260 270 280 290 300
KHYMEKEIYE QPISIQNTLN NRIKKDTINF SELGDREKKF FLNAEHIQIV
310 320 330 340 350
ACGTSYHAAM VSRYWFESLA NIPCDVEIAS EFSSRKLAVR KKSVFITLSQ
360 370 380 390 400
SGETADTLAA LRISKKLGYL GSLTICNMKG SSLVQESDCY LLTKAGIEIG
410 420 430 440 450
VASTKSFTTQ LTVLLMLIAK ITKLKKQKNN IEKKIAQILS LLPSKVEAIL
460 470 480 490 500
KKNTLIKTLA NQLCNKKNIL FLGRGDQYPI AMEGALKLKE ISYIHAEAYP
510 520 530 540 550
SGELKHGPLA LIDKNIPVII TAPKNSLLEK TKKNIKEICA RGGIIYVFSD
560 570 580 590 600
QEIDLEKNMT IIKIPYVEEI IAPILYIIPL QLLAYYIALS KGKNIDQPRH

LAKSVTVE
Length:608
Mass (Da):68,477
Last modified:January 23, 2007 - v3
Checksum:i508A3C69D37BAB86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67598.1.
RefSeqiNP_660387.1. NC_004061.1.
WP_011053564.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67598; AAM67598; BUsg_027.
GeneIDi1005843.
KEGGibas:BUsg027.
PATRICi21246811. VBIBucAph100086_0027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67598.1 .
RefSeqi NP_660387.1. NC_004061.1.
WP_011053564.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8KA75.
SMRi Q8KA75. Positions 2-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg027.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67598 ; AAM67598 ; BUsg_027 .
GeneIDi 1005843.
KEGGi bas:BUsg027.
PATRICi 21246811. VBIBucAph100086_0027.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-28-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiGLMS_BUCAP
AccessioniPrimary (citable) accession number: Q8KA75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3