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Reviewed, UniProtKB/Swiss-Prot Q8KA75 (GLMS_BUCAP)

Last modified November 24, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
    EC=2.6.1.16
Alternative name(s):
    Hexosephosphate aminotransferase
    D-fructose-6-phosphate amidotransferase
    GFAT
    L-glutamine-D-fructose-6-phosphate amidotransferase
    Glucosamine-6-phosphate synthase
Gene names
Name: glmS
Ordered Locus Names: BUsg_027
OrganismBuchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]
Taxonomic identifier98794 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. HAMAP MF_00164

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 glutamine amidotransferase type-2 domain.

Contains 2 SIS domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 608607Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] HAMAP MF_00164
PRO_0000135312

Regions

Domain2 – 219218Glutamine amidotransferase type-2
Domain287 – 427141SIS 1
Domain459 – 598140SIS 2

Sites

Active site21Nucleophile; for GATase activity By similarity
Active site6031For Fru-6P isomerization activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KA75-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 508A3C69D37BAB86

FASTA60868,477
        10         20         30         40         50         60 
MCGIVAAVTQ RNIIDFLLEG IKKLEYRGYD SSGLAIINKN QNIVRIRCVG RVNKLLKKVK 

        70         80         90        100        110        120 
KKKLFSNIGL AHTRWATHGQ VSEKNTHPHI SSHIAVVHNG VIENNTKLRH FLEKKGYIFY 

       130        140        150        160        170        180 
SDTDTEVIAH LLHWEQTKTG ESLVEVIQRS KMKLNGNYSM VVMDAYNSSR LIAVRSGSPL 

       190        200        210        220        230        240 
VIGLGIKENF IASDQIALLN ITKRFIYLEE GDTAIVETKK INIFNKNNLI IKRKEITSNV 

       250        260        270        280        290        300 
KYKSINKGKY KHYMEKEIYE QPISIQNTLN NRIKKDTINF SELGDREKKF FLNAEHIQIV 

       310        320        330        340        350        360 
ACGTSYHAAM VSRYWFESLA NIPCDVEIAS EFSSRKLAVR KKSVFITLSQ SGETADTLAA 

       370        380        390        400        410        420 
LRISKKLGYL GSLTICNMKG SSLVQESDCY LLTKAGIEIG VASTKSFTTQ LTVLLMLIAK 

       430        440        450        460        470        480 
ITKLKKQKNN IEKKIAQILS LLPSKVEAIL KKNTLIKTLA NQLCNKKNIL FLGRGDQYPI 

       490        500        510        520        530        540 
AMEGALKLKE ISYIHAEAYP SGELKHGPLA LIDKNIPVII TAPKNSLLEK TKKNIKEICA 

       550        560        570        580        590        600 
RGGIIYVFSD QEIDLEKNMT IIKIPYVEEI IAPILYIIPL QLLAYYIALS KGKNIDQPRH 


LAKSVTVE 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE013218 Genomic DNA. Translation: AAM67598.1.
RefSeqNP_660387.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1005843.
GenomeReviewsGene locus BUsg_027 in contig AE013218_GR.
KEGGbas:BUsg027.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8KA75.
OMAQPKAIRD

Enzyme and pathway databases

BioCycBAPH198804:BUSG027-MON.

Family and domain databases

HAMAPMF_00164.
[Tree]
InterProIPR000583. GATase_2.
IPR017932. GATase_II.
IPR005855. GlmS_trans.
IPR001347. SIS.
[Graphical view]
PfamPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
TIGRFAMsTIGR01135. glmS. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLMS_BUCAP
AccessionPrimary (citable) accession number: Q8KA75
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: January 23, 2007
Last modified: November 24, 2009
This is version 47 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents