Q8KA72 (METR_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator metR

Gene names

Name:	metR
Ordered Locus Names:	BUsg_030

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Activator Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	HTH-type transcriptional regulator metR		PRO_0000105678
Regions
	Domain	1 – 59	59	HTH lysR-type
	DNA binding	19 – 38	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8KA72 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9745DD65DAF8BC34	FASTA	312	36,186
	10 20 30 40 50 60 MIEIKHLRTL QALKNNGSLS AAAIQLHQTQ SAISHQFNEL EKKLGFKLFI RKSNPIKFTA 70 80 90 100 110 120 QGEILLQLSK EILPKIHKAI QNCKKTHQMI IKLAIECHSC IQWLTPALKI FQKKWPRVEI 130 140 150 160 170 180 DFYSDMIFSP QPSLQQGKLD IVLTSEVLPR SNLFYFPIFD FEVRLVLSPN HPLAQKKHNI 190 200 210 220 230 240 LPEDLISEIL MIYPVKRDKL DIWKFFLQPA GIIPIFKNVN NTLLLIQMVA AKMGITALPH 250 260 270 280 290 300 WVVDTFEKQG LVVTKKLGDG IWKRLYAAIR DGDQKELIIK NFIYAIRLHV CTHLKFIRDT 310 QKPHFFKNVK NI

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67601.1.
RefSeq	NP_660390.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8KA72.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000072; EBBUCP00000000072; EBBUCG00000000072.
GeneID	1005846.
GenomeReviews	Gene locus BUsg_030 in contig AE013218_GR.
KEGG	bas:BUsg030.
PATRIC	21246817. VBIBucAph100086_0030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG685425.
OMA	WAVHEYS.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG030-MONOMER.
Family and domain databases
InterPro	IPR005119. LysR_subst-bd. IPR000847. Tscrpt_reg_HTH_LysR. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K03576.
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PRINTS	PR00039. HTHLYSR.
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

METR_BUCAP

Accession

Primary (citable) accession number: Q8KA72

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program