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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi640ZincUniRule annotation1
Metal bindingi642ZincUniRule annotation1
Metal bindingi725ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-32-MONOMER
UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:BUsg_031
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000986201 – 7575-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseAdd BLAST757

Proteomic databases

PRIDEiQ8KA71

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg031

Structurei

3D structure databases

ProteinModelPortaliQ8KA71
SMRiQ8KA71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DSS Bacteria
COG0620 LUCA
KOiK00549
OMAiGRNIWKN
OrthoDBiPOG091H0282

Family and domain databases

Gene3Di3.20.20.210, 4 hits
HAMAPiMF_00172 Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits
TIGRFAMsiTIGR01371 met_syn_B12ind, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KA71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIFNHTLGF PRIGLNRELK KAQEDYWSGN LLYEDFLCVG SQLRRENWKK
60 70 80 90 100
QKDAGIDYIP VGDFAWYDHV LSTSMMLGNI PERHLNVNDN KIDLDCLFRI
110 120 130 140 150
ARGCSPDVAA SEMTKWFNTN YHYIVPEFNK NRILKFSWKQ ILEETDEALL
160 170 180 190 200
LGYKVKPIIL GPITYLWLGK IKGEYFDRLD LLKNILPIYK QVLRELSQRN
210 220 230 240 250
IDFVQIDEPA LVLDLPEKWK KAYSYAYEYL NGTTKILLTT YFDSIEHNIE
260 270 280 290 300
YIRDLPIYGI HIDLVFGKYN LFDFNSKLPK EWILSLGVIN GRNVWRADLI
310 320 330 340 350
KLFKSISTIL KFRKKLLIGS SCSLLHSPID LQKEKNLDKE SKKWFSFAVQ
360 370 380 390 400
KCTELSLLSK ALNKNDTDSI QKWCSSIYER NFSKRVQKIE VQNRLSEILN
410 420 430 440 450
VNFKRSDSYN IRSREQKKKF NLPILPTTTI GSFPQTLQIR KLRRDYKQGL
460 470 480 490 500
INDVDYEIGI KKHIKEVIKE QEKLGIDVLV HGEPERNDMV EYFGENLDGF
510 520 530 540 550
IFTDNGWVQS YGSRCVKPPI IIGDVSRLKP ITVKWSKYAQ SLTDKPVKAM
560 570 580 590 600
LTGPVTILFW SFPREDISLE KIAKQIGLAL RDEVLDLEKE KIEIIQIDEP
610 620 630 640 650
ALREGLPLRK SLWNEYLSWA VDAFRLSSSG VKNTTQIHTH MCYCEFHDIM
660 670 680 690 700
HAISFLDADV ITIETARSDM ELLKSFKTFK YPNEIGPGVY DIHSSNIPSI
710 720 730 740 750
TSIKFLLNKA IAYIPVERIW VNPDCGLKTR NWNETILALK NMVCAAKEMR

DKIKKIT
Length:757
Mass (Da):88,098
Last modified:October 1, 2002 - v1
Checksum:i637B1D9532325BCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67602.1
RefSeqiWP_011053568.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67602; AAM67602; BUsg_031
KEGGibas:BUsg_031

Similar proteinsi

Entry informationi

Entry nameiMETE_BUCAP
AccessioniPrimary (citable) accession number: Q8KA71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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