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Q8KA71

- METE_BUCAP

UniProt

Q8KA71 - METE_BUCAP

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

    Catalytic activityi

    5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi640 – 6401ZincUniRule annotation
    Metal bindingi642 – 6421ZincUniRule annotation
    Metal bindingi725 – 7251ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-32-MONOMER.
    UniPathwayiUPA00051; UER00082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
    Alternative name(s):
    Cobalamin-independent methionine synthaseUniRule annotation
    Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:BUsg_031
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7577575-methyltetrahydropteroyltriglutamate--homocysteine methyltransferasePRO_0000098620Add
    BLAST

    Proteomic databases

    PRIDEiQ8KA71.

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg031.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KA71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0620.
    KOiK00549.
    OMAiFKANPAH.
    OrthoDBiEOG6FFS3G.

    Family and domain databases

    HAMAPiMF_00172. Meth_synth.
    InterProiIPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view]
    PfamiPF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8KA71-1 [UniParc]FASTAAdd to Basket

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    MTIFNHTLGF PRIGLNRELK KAQEDYWSGN LLYEDFLCVG SQLRRENWKK    50
    QKDAGIDYIP VGDFAWYDHV LSTSMMLGNI PERHLNVNDN KIDLDCLFRI 100
    ARGCSPDVAA SEMTKWFNTN YHYIVPEFNK NRILKFSWKQ ILEETDEALL 150
    LGYKVKPIIL GPITYLWLGK IKGEYFDRLD LLKNILPIYK QVLRELSQRN 200
    IDFVQIDEPA LVLDLPEKWK KAYSYAYEYL NGTTKILLTT YFDSIEHNIE 250
    YIRDLPIYGI HIDLVFGKYN LFDFNSKLPK EWILSLGVIN GRNVWRADLI 300
    KLFKSISTIL KFRKKLLIGS SCSLLHSPID LQKEKNLDKE SKKWFSFAVQ 350
    KCTELSLLSK ALNKNDTDSI QKWCSSIYER NFSKRVQKIE VQNRLSEILN 400
    VNFKRSDSYN IRSREQKKKF NLPILPTTTI GSFPQTLQIR KLRRDYKQGL 450
    INDVDYEIGI KKHIKEVIKE QEKLGIDVLV HGEPERNDMV EYFGENLDGF 500
    IFTDNGWVQS YGSRCVKPPI IIGDVSRLKP ITVKWSKYAQ SLTDKPVKAM 550
    LTGPVTILFW SFPREDISLE KIAKQIGLAL RDEVLDLEKE KIEIIQIDEP 600
    ALREGLPLRK SLWNEYLSWA VDAFRLSSSG VKNTTQIHTH MCYCEFHDIM 650
    HAISFLDADV ITIETARSDM ELLKSFKTFK YPNEIGPGVY DIHSSNIPSI 700
    TSIKFLLNKA IAYIPVERIW VNPDCGLKTR NWNETILALK NMVCAAKEMR 750
    DKIKKIT 757
    Length:757
    Mass (Da):88,098
    Last modified:October 1, 2002 - v1
    Checksum:i637B1D9532325BCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67602.1.
    RefSeqiNP_660391.1. NC_004061.1.
    WP_011053568.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67602; AAM67602; BUsg_031.
    GeneIDi1005847.
    KEGGibas:BUsg031.
    PATRICi21246819. VBIBucAph100086_0031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67602.1 .
    RefSeqi NP_660391.1. NC_004061.1.
    WP_011053568.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8KA71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg031.

    Proteomic databases

    PRIDEi Q8KA71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67602 ; AAM67602 ; BUsg_031 .
    GeneIDi 1005847.
    KEGGi bas:BUsg031.
    PATRICi 21246819. VBIBucAph100086_0031.

    Phylogenomic databases

    eggNOGi COG0620.
    KOi K00549.
    OMAi FKANPAH.
    OrthoDBi EOG6FFS3G.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00082 .
    BioCyci BAPH198804:GHMG-32-MONOMER.

    Family and domain databases

    HAMAPi MF_00172. Meth_synth.
    InterProi IPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view ]
    Pfami PF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiMETE_BUCAP
    AccessioniPrimary (citable) accession number: Q8KA71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3