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Q8KA71

- METE_BUCAP

UniProt

Q8KA71 - METE_BUCAP

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Protein
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Gene
metE, BUsg_031
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi640 – 6401Zinc By similarity
Metal bindingi642 – 6421Zinc By similarity
Metal bindingi725 – 7251Zinc By similarity

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-32-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC:2.1.1.14)
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene namesi
Name:metE
Ordered Locus Names:BUsg_031
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7577575-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation
PRO_0000098620Add
BLAST

Proteomic databases

PRIDEiQ8KA71.

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg031.

Structurei

3D structure databases

ProteinModelPortaliQ8KA71.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0620.
KOiK00549.
OMAiFKANPAH.
OrthoDBiEOG6FFS3G.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KA71-1 [UniParc]FASTAAdd to Basket

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MTIFNHTLGF PRIGLNRELK KAQEDYWSGN LLYEDFLCVG SQLRRENWKK    50
QKDAGIDYIP VGDFAWYDHV LSTSMMLGNI PERHLNVNDN KIDLDCLFRI 100
ARGCSPDVAA SEMTKWFNTN YHYIVPEFNK NRILKFSWKQ ILEETDEALL 150
LGYKVKPIIL GPITYLWLGK IKGEYFDRLD LLKNILPIYK QVLRELSQRN 200
IDFVQIDEPA LVLDLPEKWK KAYSYAYEYL NGTTKILLTT YFDSIEHNIE 250
YIRDLPIYGI HIDLVFGKYN LFDFNSKLPK EWILSLGVIN GRNVWRADLI 300
KLFKSISTIL KFRKKLLIGS SCSLLHSPID LQKEKNLDKE SKKWFSFAVQ 350
KCTELSLLSK ALNKNDTDSI QKWCSSIYER NFSKRVQKIE VQNRLSEILN 400
VNFKRSDSYN IRSREQKKKF NLPILPTTTI GSFPQTLQIR KLRRDYKQGL 450
INDVDYEIGI KKHIKEVIKE QEKLGIDVLV HGEPERNDMV EYFGENLDGF 500
IFTDNGWVQS YGSRCVKPPI IIGDVSRLKP ITVKWSKYAQ SLTDKPVKAM 550
LTGPVTILFW SFPREDISLE KIAKQIGLAL RDEVLDLEKE KIEIIQIDEP 600
ALREGLPLRK SLWNEYLSWA VDAFRLSSSG VKNTTQIHTH MCYCEFHDIM 650
HAISFLDADV ITIETARSDM ELLKSFKTFK YPNEIGPGVY DIHSSNIPSI 700
TSIKFLLNKA IAYIPVERIW VNPDCGLKTR NWNETILALK NMVCAAKEMR 750
DKIKKIT 757
Length:757
Mass (Da):88,098
Last modified:October 1, 2002 - v1
Checksum:i637B1D9532325BCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67602.1.
RefSeqiNP_660391.1. NC_004061.1.
WP_011053568.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67602; AAM67602; BUsg_031.
GeneIDi1005847.
KEGGibas:BUsg031.
PATRICi21246819. VBIBucAph100086_0031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67602.1 .
RefSeqi NP_660391.1. NC_004061.1.
WP_011053568.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8KA71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg031.

Proteomic databases

PRIDEi Q8KA71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67602 ; AAM67602 ; BUsg_031 .
GeneIDi 1005847.
KEGGi bas:BUsg031.
PATRICi 21246819. VBIBucAph100086_0031.

Phylogenomic databases

eggNOGi COG0620.
KOi K00549.
OMAi FKANPAH.
OrthoDBi EOG6FFS3G.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci BAPH198804:GHMG-32-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiMETE_BUCAP
AccessioniPrimary (citable) accession number: Q8KA71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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