Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8KA70

- PUR9_BUCAP

UniProt

Q8KA70 - PUR9_BUCAP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-33-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:BUsg_032
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Bifunctional purine biosynthesis protein PurHPRO_0000192077Add
BLAST

Proteomic databases

PRIDEiQ8KA70.

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg032.

Structurei

3D structure databases

ProteinModelPortaliQ8KA70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KA70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLNNIIKNA LVSLSDKTDL LKISKILAEK KINLFCTGGT ADVLKKNKIP
60 70 80 90 100
VLEISDYTNF PEIMNGRLKT LHPKIIGGIL GRREKDQKIM KLHNLIPIDI
110 120 130 140 150
VIVNFYPFEK IQNRKEFTIE EIIDNIDIGG PTLVRAAAKN YKDVIVIVDL
160 170 180 190 200
SDFTSCIQLI NTNTVSLETR FDLATKAFKY TALYEEIISK YFLKKNPYRK
210 220 230 240 250
KHQKNIFPNE FQLNFIKKQD LRYGENQHQK SSFYIEKEIL KSGTISSSNQ
260 270 280 290 300
IQGKNLSYNN ICDADIALEC VKEFSKPTCV IVKHGNPCGV SESNSLIKAY
310 320 330 340 350
FSAYNADPIS AFGGIIAFNC LLDLDTAQEI VKKQFVEVII APEIDEMAVK
360 370 380 390 400
ILKRKKNIRL LICGKIEKNK KGLDFKRITN GLLIQEYDCD EINAKNFDFV
410 420 430 440 450
TNRLPTEKEL EDAIFSWKVA KFVKSNAIVY SLNKTTIGIG AGQTSRIDAT
460 470 480 490 500
KLANLKVKDR NHNNTTGATM ASDAFFPFRD GIDNAALIGI SCIIQPGGSI
510 520
RDKEVIESAN EHNISMIFTK KRHFKH
Length:526
Mass (Da):59,422
Last modified:October 1, 2002 - v1
Checksum:i7F0F13954EF902A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67603.1.
RefSeqiNP_660392.1. NC_004061.1.
WP_011053569.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67603; AAM67603; BUsg_032.
GeneIDi1005848.
KEGGibas:BUsg032.
PATRICi21246821. VBIBucAph100086_0032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67603.1 .
RefSeqi NP_660392.1. NC_004061.1.
WP_011053569.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8KA70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg032.

Proteomic databases

PRIDEi Q8KA70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67603 ; AAM67603 ; BUsg_032 .
GeneIDi 1005848.
KEGGi bas:BUsg032.
PATRICi 21246821. VBIBucAph100086_0032.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BAPH198804:GHMG-33-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiPUR9_BUCAP
AccessioniPrimary (citable) accession number: Q8KA70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3