Reviewed,
UniProtKB/Swiss-Prot Q8KA70 (PUR9_BUCAP)
Last modified
November 3, 2009.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional purine biosynthesis protein purH Including the following 2 domains: 1- Recommended name: Phosphoribosylaminoimidazolecarboxamide formyltransferase EC=2.1.2.3 Alternative name(s): AICAR transformylase 2- Recommended name: IMP cyclohydrolase EC=3.5.4.10 Alternative name(s): Inosinicase IMP synthetase ATIC | ||||
| Gene names |
| ||||
| Organism | Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 98794 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera |
Protein attributes
| Sequence length | 526 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 |
| Domain | The IMP cyclohydrolase activity resides in the N-terminal region By similarity. |
| Sequence similarities | Belongs to the purH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Hydrolase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 526 | 526 | Bifunctional purine biosynthesis protein purH HAMAP MF_00139 | PRO_0000192077 | |||
Sequences
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References
| [1] | "50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AE013218 Genomic DNA. Translation: AAM67603.1. | |
| RefSeq | NP_660392.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1G8M based on UniProtKB P31335. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1005848. |
| GenomeReviews | Gene locus BUsg_032 in contig AE013218_GR. |
| KEGG | bas:BUsg032. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8KA70. |
| OMA | VVKHVKS. |
Enzyme and pathway databases | |
| BioCyc | BAPH198804:BUSG032-MON. |
Family and domain databases | |
| HAMAP | MF_00139. [Tree] |
| InterPro | IPR002695. AICARFT_IMPCHas. IPR013982. AICARFT_IMPCHas_formly. IPR011607. MGS. [Graphical view] |
| PANTHER | PTHR11692. AICARFT_IMPCHas. 1 hit. |
| Pfam | PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view] |
| PIRSF | PIRSF000414. AICARFT_IMPCHas. 1 hit. |
| SMART | SM00798. AICARFT_IMPCHas. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00355. purH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR9_BUCAP | ||||||||
| Accession | Primary (citable) accession number: Q8KA70 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Buchnera aphidicola (subsp. Schizaphis graminum) Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


