ID   METF_BUCAP              Reviewed;         292 AA.
AC   Q8KA62;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=5,10-methylenetetrahydrofolate reductase;
DE            EC=1.5.1.20;
GN   Name=metF; OrderedLocusNames=BUsg_043;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-
CC       methylenetetrahydrofolate + NAD(P)H.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate pathway.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family.
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DR   EMBL; AE013218; AAM67614.1; -; Genomic_DNA.
DR   RefSeq; NP_660403.1; -.
DR   HSSP; P00394; 1B5T.
DR   GeneID; 1005859; -.
DR   GenomeReviews; AE013218_GR; BUsg_043.
DR   KEGG; bas:BUsg043; -.
DR   HOGENOM; Q8KA62; -.
DR   OMA; Q8KA62; FFPPKTP.
DR   BioCyc; BAPH198804:BUSG043-MON; -.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NADPH)...; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   InterPro; IPR004620; MTHF_reductase_bac.
DR   Pfam; PF02219; MTHFR; 1.
DR   TIGRFAMs; TIGR00676; fadh2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; FAD; Flavoprotein;
KW   Methionine biosynthesis; NAD; NADP; Oxidoreductase.
FT   CHAIN         1    292       5,10-methylenetetrahydrofolate reductase.
FT                                /FTId=PRO_0000190259.
SQ   SEQUENCE   292 AA;  33676 MW;  0660895E1B065E71 CRC64;
     MNFLHQYYQD IIKKKLENLN DKIQCSFEFF PPKNLDTEKK LFSSVVKLSL LKPFLFSVTY
     GANSGERKKT YSIVQRIHKK TGITTAPHLT CVDASLSELK EIAKFYWENG IRSIVALRGD
     VPNKSYQHKI YALDLVVLLK KIADFDISVA AYPEIHPESK NAQSDILNLK KKADAGANRA
     ITQFFFNVES YLRFRDNCIK NNINIEIIPG ILPIYNFEQL KKFSSMTNVS IPKWMFEMFN
     GLDEDLETQK IIGSNIVINI VKTLLYEGVK NFHFYTLNKS DVIYSICHMF GL
//