Q8KA61 (ARGC_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BUsg_045

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112392
Sites
	Active site	154	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8KA61 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9F7487A9B3816B77	FASTA	334	37,835
	10 20 30 40 50 60 MLNVLIVGAS GYSGAELVNY INRHMFSKIK KIFVSENSSH IGKLFSELHQ EFKNIIDLPF 70 80 90 100 110 120 EAINYDTLIE KDIDAVFLAT DHHVSYSLVP FFLSLNCVVF DLSGAYRVKN TDTYLKYYGF 130 140 150 160 170 180 SHQHQDILKR SVYGLAEWNK QEIKKAELIA VPGCYATCIQ LALKPLIKEN FLNDEFIPII 190 200 210 220 230 240 NAISGVSGAG RKANITNSFC EVSLHPYNVF THRHTPEIIE HLGIPVIFIP HLGSFSRGIL 250 260 270 280 290 300 ASITCKLKCN FTFQDIYNLY NTVYKEKPLI RVYEKNFPSI KAVVKLPFCD IGFIIQDKYI 310 320 330 VIIAAEDNLL KGAAAQAIQC FNIRFGFSEI ESII

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67616.1.
RefSeq	NP_660405.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8KA61.
SMR	Q8KA61. Positions 1-334.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000220; EBBUCP00000000220; EBBUCG00000000220.
GeneID	1005861.
GenomeReviews	Gene locus BUsg_045 in contig AE013218_GR.
KEGG	bas:BUsg045.
PATRIC	21246855. VBIBucAph100086_0045.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007856.
HOGENOM	HBG294213.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG045-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BUCAP

Accession

Primary (citable) accession number: Q8KA61

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program