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Q8KA61 (ARGC_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:BUsg_045
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera ›

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP-Rule MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP-Rule MF_00150

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: HAMAP

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334N-acetyl-gamma-glutamyl-phosphate reductase HAMAP-Rule MF_00150
PRO_0000112392

Sites

Active site1541 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KA61 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9F7487A9B3816B77

FASTA33437,835
        10         20         30         40         50         60 
MLNVLIVGAS GYSGAELVNY INRHMFSKIK KIFVSENSSH IGKLFSELHQ EFKNIIDLPF 

        70         80         90        100        110        120 
EAINYDTLIE KDIDAVFLAT DHHVSYSLVP FFLSLNCVVF DLSGAYRVKN TDTYLKYYGF 

       130        140        150        160        170        180 
SHQHQDILKR SVYGLAEWNK QEIKKAELIA VPGCYATCIQ LALKPLIKEN FLNDEFIPII 

       190        200        210        220        230        240 
NAISGVSGAG RKANITNSFC EVSLHPYNVF THRHTPEIIE HLGIPVIFIP HLGSFSRGIL 

       250        260        270        280        290        300 
ASITCKLKCN FTFQDIYNLY NTVYKEKPLI RVYEKNFPSI KAVVKLPFCD IGFIIQDKYI 

       310        320        330 
VIIAAEDNLL KGAAAQAIQC FNIRFGFSEI ESII

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013218 Genomic DNA. Translation: AAM67616.1.
RefSeqNP_660405.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8KA61.
SMRQ8KA61. Positions 1-334.
ModBaseSearch...

Protein-protein interaction databases

STRING198804.BUsg045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67616; AAM67616; BUsg_045.
GeneID1005861.
KEGGbas:BUsg045.
PATRIC21246855. VBIBucAph100086_0045.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0002.
KOK00145.
OMAVCRIAVH.
ProtClustDBPRK00436.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-117-MONOMER.
UniPathwayUPA00068; UER00108.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00150. ArgC_type1.
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. argC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_BUCAP
AccessionPrimary (citable) accession number: Q8KA61
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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