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Q8KA59 (ARLY_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase

Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:BUsg_048
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_0000137749

Sequences

Sequence LengthMass (Da)Tools
Q8KA59 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: ADD7D45577219C6A

FASTA45952,044
        10         20         30         40         50         60 
MSLWGGRFLD ESNETFKKFN ASLPFDYILV KEDIFASIAW SKSLVEVGVL TQEEQKKIES 

        70         80         90        100        110        120 
ALISLKEEIY NNSKKILESD YEDIHSWIEA NLIKKIGELG KKLHTGRSRN DQITTDLKLW 

       130        140        150        160        170        180 
CKRKIFVLLD SIINLQKNFI FVAELNDDVI MPGYTHLQRA QPITFSYWCL AYVQMFKRDV 

       190        200        210        220        230        240 
SRLKDILKRL DISPLGSGAL SGTAWNINRK KLAISMGFSS ETNNALDSVS DRDYLIELLS 

       250        260        270        280        290        300 
ASSISMTHLS RFSEDLIFFN SSEANFIELS DSITSGSSLM PQKKNPDALE LIRAKCGRVH 

       310        320        330        340        350        360 
GALVSILVVL KSLPLSYNKD LQEDKEGLFD SLKTWNDSLL IASLVLKNIK LNRLSCRKAA 

       370        380        390        400        410        420 
EKGYSNATEI ADYLVKKGMT FREAHHVSGK LVLRAIKENK SLNDLDLSIF QSYSALITDD 

       430        440        450 
IYKNITLEAC LEKRSSKGGV APNEIRKEIF KEKERLNIL 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67619.1.
RefSeqNP_660408.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8KA59.
SMRQ8KA59. Positions 3-456.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg048.

Proteomic databases

PRIDEQ8KA59.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67619; AAM67619; BUsg_048.
GeneID1005864.
KEGGbas:BUsg048.
PATRIC21246861. VBIBucAph100086_0048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
KOK01755.
OMAKEGIFDA.
OrthoDBEOG6P5ZF8.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-53-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00149. FUMRATELYASE.
SUPFAMSSF48557. SSF48557. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BUCAP
AccessionPrimary (citable) accession number: Q8KA59
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names