Reviewed, UniProtKB/Swiss-Prot Q8KA56 (GCP_BUCAP)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BUsg_055

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000096960
Sites
	Metal binding	110	1	Zinc Potential
	Metal binding	114	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8KA56-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 533D071D43158583	FASTA	337	37,383
	10 20 30 40 50 60 MKVLGIETSC DDTGIAIYDV SKGLLINELH SQKKIHANYG GIIPELASRE HTRKIIFLLD 70 80 90 100 110 120 KIFKEKNIMK EIDLIAYTAG PGLAGSLLVG ATFACSLGFS LNIPVLPVNH MEAHLLSPML 130 140 150 160 170 180 EYKSMQFPFI ALLVSGKHTQ IIAAYELGKY EILGNSLDDA AGEAFDKVSK MLGLKYPSGR 190 200 210 220 230 240 ELSSLAAQGI KNYFYFPRPM IHHSSLNFSF SGLKTFTSKV ISNNTLNIQQ KANIARAFED 250 260 270 280 290 300 AVIDVLLIKT KKALYKKGWK RLVIAGGVSA NTVLRKRSKD MMENVFHGKV FYSSLKFCTD 310 320 330 NGAMIAYLGS LRYKEASVSQ LEIIVKPKWS IDKLSYI

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67626.1.
RefSeq	NP_660415.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	1005871.
GenomeReviews	Gene locus BUsg_055 in contig AE013218_GR.
KEGG	bas:BUsg055.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8KA56.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG055-MON.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BUCAP

Accession

Primary (citable) accession number: Q8KA56

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)