Q8KA52 (UPPP_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	BUsg_059

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151123
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	215 – 235	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8KA52 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: B05351DDDFBE510A	FASTA	264	29,976
	10 20 30 40 50 60 MFFFHKIVIP IIIGIIQGIT EFFPVSSTGH MIIFIDWLDI KNKDTKILEI FVQLGSTISV 70 80 90 100 110 120 FLFFYKKIIQ ILQLPMQKES NEKKNIHVLI SILPTMFLGL IFYNKIKSLF NPTNVMYALI 130 140 150 160 170 180 LGGFFLIIAE KFKPKKPKTN SIKEINLVQS LIIGCFQTLC LYPGFSRSGA SIAIATLLGF 190 200 210 220 230 240 KRSVAVNFSF IISIPLIAGA SVLDLIKNIQ NVNMLNIPYL FSGFTISFII SFLLIKKFIT 250 260 ILNKVSLTFF GIYRFLIAGI IYFI

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67630.1.
RefSeq	NP_660419.1. NC_004061.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg059.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67630; AAM67630; BUsg_059.
GeneID	1005875.
KEGG	bas:BUsg059.
PATRIC	21246883. VBIBucAph100086_0059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-131-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_BUCAP

Accession

Primary (citable) accession number: Q8KA52

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program