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Q8KA52

- UPPP_BUCAP

UniProt

Q8KA52 - UPPP_BUCAP

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, upk, BUsg_059
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-64-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:BUsg_059
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei86 – 10621Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST
Transmembranei186 – 20621Helical; Reviewed predictionAdd
BLAST
Transmembranei215 – 23521Helical; Reviewed predictionAdd
BLAST
Transmembranei244 – 26421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Undecaprenyl-diphosphataseUniRule annotationPRO_0000151123Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg059.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8KA52-1 [UniParc]FASTAAdd to Basket

« Hide

MFFFHKIVIP IIIGIIQGIT EFFPVSSTGH MIIFIDWLDI KNKDTKILEI    50
FVQLGSTISV FLFFYKKIIQ ILQLPMQKES NEKKNIHVLI SILPTMFLGL 100
IFYNKIKSLF NPTNVMYALI LGGFFLIIAE KFKPKKPKTN SIKEINLVQS 150
LIIGCFQTLC LYPGFSRSGA SIAIATLLGF KRSVAVNFSF IISIPLIAGA 200
SVLDLIKNIQ NVNMLNIPYL FSGFTISFII SFLLIKKFIT ILNKVSLTFF 250
GIYRFLIAGI IYFI 264
Length:264
Mass (Da):29,976
Last modified:October 1, 2002 - v1
Checksum:iB05351DDDFBE510A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67630.1.
RefSeqiNP_660419.1. NC_004061.1.
WP_011053596.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67630; AAM67630; BUsg_059.
GeneIDi1005875.
KEGGibas:BUsg059.
PATRICi21246883. VBIBucAph100086_0059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67630.1 .
RefSeqi NP_660419.1. NC_004061.1.
WP_011053596.1. NC_004061.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67630 ; AAM67630 ; BUsg_059 .
GeneIDi 1005875.
KEGGi bas:BUsg059.
PATRICi 21246883. VBIBucAph100086_0059.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-64-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiUPPP_BUCAP
AccessioniPrimary (citable) accession number: Q8KA52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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