Q8KA51 (PTGA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-specific phosphotransferase enzyme IIA component
EC=2.7.1.-

Alternative name(s):
EIIA-Glc
EIII-Glc
PTS system glucose-specific EIIA component

Gene names

Name:	crr
Ordered Locus Names:	BUsg_060

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport By similarity.
Catalytic activity	Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Subcellular location	Cytoplasm By similarity.
Domain	The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence similarities	Contains 1 PTS EIIA type-1 domain.

Ontologies

Keywords
Biological process	Phosphotransferase system Sugar transport Transport
Cellular component	Cytoplasm
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Glucose-specific phosphotransferase enzyme IIA component		PRO_0000186539
Regions
	Domain	37 – 141	105	PTS EIIA type-1
Sites
	Active site	89	1	Tele-phosphohistidine intermediate By similarity
	Site	74	1	Important for phospho-donor activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8KA51 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9C71B05BC7907551	FASTA	167	18,329
	10 20 30 40 50 60 MSFFSGFFNK KKSKYSKKID ILAPLSGDII NIEDVPDVVF SKKIVGDGIA INPTGNKILA 70 80 90 100 110 120 PINGTIGKIL NSMHAFSIIS EEGVELFVHF GIDTVKLRGE GFKQIAQDNQ KVKIGDTIIL 130 140 150 160 FDLNLLKEKA RSILTPVVIS NIEKFKNIEK SSGTIIAGKT IIMSLYN

References

[1]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67631.1.
RefSeq	NP_660420.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8KA51.
SMR	Q8KA51. Positions 6-165.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000319; EBBUCP00000000319; EBBUCG00000000319.
GeneID	1005876.
GenomeReviews	Gene locus BUsg_060 in contig AE013218_GR.
KEGG	bas:BUsg060.
PATRIC	21246885. VBIBucAph100086_0060.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008103.
HOGENOM	HBG517865.
OMA	RRLISGQ.
ProtClustDB	PRK09439.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG060-MONOMER.
Family and domain databases
InterPro	IPR011055. Dup_hybrid_motif. IPR001127. PTS_EIIA_1_perm. [Graphical view]
KO	K02777.
Pfam	PF00358. PTS_EIIA_1. 1 hit. [Graphical view]
SUPFAM	SSF51261. Dup_hybrid_motif. 1 hit.
TIGRFAMs	TIGR00830. PTBA. 1 hit.
PROSITE	PS51093. PTS_EIIA_TYPE_1. 1 hit. PS00371. PTS_EIIA_TYPE_1_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTGA_BUCAP

Accession

Primary (citable) accession number: Q8KA51

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program