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Q8KA28

- FABB_BUCAP

UniProt

Q8KA28 - FABB_BUCAP

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

fabB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-93-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase I
    Beta-ketoacyl-ACP synthase I
    Short name:
    KAS I
    Gene namesi
    Name:fabB
    Ordered Locus Names:BUsg_084
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4074073-oxoacyl-[acyl-carrier-protein] synthase 1PRO_0000180309Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KA28.
    SMRiQ8KA28. Positions 1-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    KOiK00647.
    OMAiNYLAMEQ.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8KA28-1 [UniParc]FASTAAdd to Basket

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    MKRVVITGFG IISSIGNNKK EVLNSLYNGI SGITFSEEMK ESGMRSQVWG    50
    NIKLENKKFF KKNKISRFMN NGSIYAFLSM EQAIKDANLQ TKQYQKNPRI 100
    GIIAGSGGGF PKYHIQGIDA IRSNRGLNSV SPYIAIKAMN SGISACLSTL 150
    FKIYGVNYSI SSACATSGHC IGNAFELIKF GKQDLIFAGG GEEVSWELAY 200
    EFDAMKALSS NFNKNPTKSS RVYDVNRDGF VISGGGGIIV IEELNCALSR 250
    SAHIYAEIIG YAATSDGKDM VVPSGDGAVR CMNLAKKQNK MLFIDYLNVH 300
    GTSTKIGDLI ELEAIKKSFF HEKKPMISAT KSMTGHALGV SGVHEIIYTL 350
    LMMKYNFIAP SINIETIEPS ADNMNIVQKT FHKKIKTALS NSFGFGGTNV 400
    SLILKKY 407
    Length:407
    Mass (Da):44,523
    Last modified:October 1, 2002 - v1
    Checksum:iCBCFC30445A34679
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67654.1.
    RefSeqiNP_660443.1. NC_004061.1.
    WP_011053620.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67654; AAM67654; BUsg_084.
    GeneIDi1005901.
    KEGGibas:BUsg084.
    PATRICi21246943. VBIBucAph100086_0086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67654.1 .
    RefSeqi NP_660443.1. NC_004061.1.
    WP_011053620.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8KA28.
    SMRi Q8KA28. Positions 1-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg084.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67654 ; AAM67654 ; BUsg_084 .
    GeneIDi 1005901.
    KEGGi bas:BUsg084.
    PATRICi 21246943. VBIBucAph100086_0086.

    Phylogenomic databases

    eggNOGi COG0304.
    KOi K00647.
    OMAi NYLAMEQ.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci BAPH198804:GHMG-93-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiFABB_BUCAP
    AccessioniPrimary (citable) accession number: Q8KA28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3