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Q8KA28

- FABB_BUCAP

UniProt

Q8KA28 - FABB_BUCAP

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase 1
Gene
fabB, BUsg_084
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641 By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-93-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name:
KAS I
Gene namesi
Name:fabB
Ordered Locus Names:BUsg_084
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4074073-oxoacyl-[acyl-carrier-protein] synthase 1
PRO_0000180309Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg084.

Structurei

3D structure databases

ProteinModelPortaliQ8KA28.
SMRiQ8KA28. Positions 1-406.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0304.
KOiK00647.
OMAiNYLAMEQ.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KA28-1 [UniParc]FASTAAdd to Basket

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MKRVVITGFG IISSIGNNKK EVLNSLYNGI SGITFSEEMK ESGMRSQVWG    50
NIKLENKKFF KKNKISRFMN NGSIYAFLSM EQAIKDANLQ TKQYQKNPRI 100
GIIAGSGGGF PKYHIQGIDA IRSNRGLNSV SPYIAIKAMN SGISACLSTL 150
FKIYGVNYSI SSACATSGHC IGNAFELIKF GKQDLIFAGG GEEVSWELAY 200
EFDAMKALSS NFNKNPTKSS RVYDVNRDGF VISGGGGIIV IEELNCALSR 250
SAHIYAEIIG YAATSDGKDM VVPSGDGAVR CMNLAKKQNK MLFIDYLNVH 300
GTSTKIGDLI ELEAIKKSFF HEKKPMISAT KSMTGHALGV SGVHEIIYTL 350
LMMKYNFIAP SINIETIEPS ADNMNIVQKT FHKKIKTALS NSFGFGGTNV 400
SLILKKY 407
Length:407
Mass (Da):44,523
Last modified:October 1, 2002 - v1
Checksum:iCBCFC30445A34679
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67654.1.
RefSeqiNP_660443.1. NC_004061.1.
WP_011053620.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67654; AAM67654; BUsg_084.
GeneIDi1005901.
KEGGibas:BUsg084.
PATRICi21246943. VBIBucAph100086_0086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67654.1 .
RefSeqi NP_660443.1. NC_004061.1.
WP_011053620.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8KA28.
SMRi Q8KA28. Positions 1-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg084.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67654 ; AAM67654 ; BUsg_084 .
GeneIDi 1005901.
KEGGi bas:BUsg084.
PATRICi 21246943. VBIBucAph100086_0086.

Phylogenomic databases

eggNOGi COG0304.
KOi K00647.
OMAi NYLAMEQ.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci BAPH198804:GHMG-93-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiFABB_BUCAP
AccessioniPrimary (citable) accession number: Q8KA28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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