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Protein

Chaperone SurA

Gene

surA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-143-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone SurA
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurA (EC:5.2.1.8)
Short name:
PPIase SurA
Rotamase SurA
Gene namesi
Name:surA
Ordered Locus Names:BUsg_133
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

Subcellular locationi

  • Periplasm By similarity

  • Note: Is capable of associating with the outer membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 432411Chaperone SurAPRO_0000025541Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg133.

Structurei

3D structure databases

ProteinModelPortaliQ8KA01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 276102PpiC 1Add
BLAST
Domaini286 – 386101PpiC 2Add
BLAST

Domaini

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition (By similarity).By similarity

Sequence similaritiesi

Contains 2 PpiC domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0760.
KOiK03771.
OMAiFGVHLIQ.
OrthoDBiEOG6M9DS4.

Family and domain databases

HAMAPiMF_01183. Chaperone_SurA.
InterProiIPR000297. PPIase_PpiC.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMiSSF109998. SSF109998. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8KA01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVYFFLILY VFLSFFSITY SKELEIDKII AIVNNQIILN SDVNQVLFSL
60 70 80 90 100
KEEDQRVKIP LKINFLRNKI IKKLITETLI LEEAKKFNIV VTDDQVNNVL
110 120 130 140 150
SKYALKKNIT IEELKRNILM NNTNTSFSYN DYFNKIKNSL KVKIIQDYVL
160 170 180 190 200
HNRVHISEKE VDLFLNKLIN TQNELKKIDI NCIFLPFIKE KNKIFIKNTK
210 220 230 240 250
ILADHFAKKI KKDASFNYYY EYFKKNNNIF LSKEIRSKSL KYLKKIFLNK
260 270 280 290 300
LKIIKKNQIL GPILGLKGFY ILKINKIENE NKENLTTEFH IQHCLIRPSV
310 320 330 340 350
ILDDKQAKNS IYYIYNNIKN KKYSFDYAVQ KLSHDVYSSH KKGDLGWIST
360 370 380 390 400
DFFSNDFRNF LTDLRKNEIS KPIKSNFGWH IIKLLDIRQV DKSNRIDKNL
410 420 430
VYRFLLEKKI KKERYNWIRQ LKKSSYIKIF KN
Length:432
Mass (Da):51,748
Last modified:October 1, 2002 - v1
Checksum:i698284DB452257ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67701.1.
RefSeqiWP_011053668.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67701; AAM67701; BUsg_133.
KEGGibas:BUsg133.
PATRICi21247047. VBIBucAph100086_0137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67701.1.
RefSeqiWP_011053668.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8KA01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67701; AAM67701; BUsg_133.
KEGGibas:BUsg133.
PATRICi21247047. VBIBucAph100086_0137.

Phylogenomic databases

eggNOGiCOG0760.
KOiK03771.
OMAiFGVHLIQ.
OrthoDBiEOG6M9DS4.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-143-MONOMER.

Family and domain databases

HAMAPiMF_01183. Chaperone_SurA.
InterProiIPR000297. PPIase_PpiC.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMiSSF109998. SSF109998. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSURA_BUCAP
AccessioniPrimary (citable) accession number: Q8KA01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.