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Q8KA01 (SURA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chaperone SurA
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurA
Short name=PPIase SurA
EC=5.2.1.8
Rotamase SurA
Gene names
Name:surA
Ordered Locus Names:BUsg_133
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera ›

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation By similarity. HAMAP-Rule MF_01183

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_01183

Subcellular location

Periplasm By similarity. Note: Is capable of associating with the outer membrane By similarity.

Domain

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition By similarity. HAMAP-Rule MF_01183

Sequence similarities

Contains 2 PpiC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 432411Chaperone SurA HAMAP-Rule MF_01183
PRO_0000025541

Regions

Domain175 – 276102PpiC 1
Domain286 – 386101PpiC 2

Sequences

Sequence LengthMass (Da)Tools
Q8KA01 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 698284DB452257ED

FASTA43251,748
        10         20         30         40         50         60 
MKVYFFLILY VFLSFFSITY SKELEIDKII AIVNNQIILN SDVNQVLFSL KEEDQRVKIP 

        70         80         90        100        110        120 
LKINFLRNKI IKKLITETLI LEEAKKFNIV VTDDQVNNVL SKYALKKNIT IEELKRNILM 

       130        140        150        160        170        180 
NNTNTSFSYN DYFNKIKNSL KVKIIQDYVL HNRVHISEKE VDLFLNKLIN TQNELKKIDI 

       190        200        210        220        230        240 
NCIFLPFIKE KNKIFIKNTK ILADHFAKKI KKDASFNYYY EYFKKNNNIF LSKEIRSKSL 

       250        260        270        280        290        300 
KYLKKIFLNK LKIIKKNQIL GPILGLKGFY ILKINKIENE NKENLTTEFH IQHCLIRPSV 

       310        320        330        340        350        360 
ILDDKQAKNS IYYIYNNIKN KKYSFDYAVQ KLSHDVYSSH KKGDLGWIST DFFSNDFRNF 

       370        380        390        400        410        420 
LTDLRKNEIS KPIKSNFGWH IIKLLDIRQV DKSNRIDKNL VYRFLLEKKI KKERYNWIRQ 

       430 
LKKSSYIKIF KN

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013218 Genomic DNA. Translation: AAM67701.1.
RefSeqNP_660490.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8KA01.
ModBaseSearch...

Protein-protein interaction databases

STRING198804.BUsg133.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67701; AAM67701; BUsg_133.
GeneID1005950.
KEGGbas:BUsg133.
PATRIC21247047. VBIBucAph100086_0137.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0760.
KOK03771.
OMAFGVHLIQ.
ProtClustDBCLSK315493.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-203-MONOMER.

Family and domain databases

HAMAPMF_01183. Chaperone_SurA.
InterProIPR000297. PPIase_PpiC.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMSSF109998. Trigger_fac_C_bac. 1 hit.
PROSITEPS01096. PPIC_PPIASE_1. False negative.
PS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSURA_BUCAP
AccessionPrimary (citable) accession number: Q8KA01
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

SIMILARITY comments

Index of protein domains and families

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