ID   APAH_BUCAP              Reviewed;         273 AA.
AC   Q8K9Z9;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=BUsg_135;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; AE013218; AAM67703.1; -; Genomic_DNA.
DR   RefSeq; NP_660492.1; -.
DR   GeneID; 1005952; -.
DR   GenomeReviews; AE013218_GR; BUsg_135.
DR   KEGG; bas:BUsg135; -.
DR   HOGENOM; Q8K9Z9; -.
DR   OMA; Q8K9Z9; LVFGHWA.
DR   BioCyc; BAPH198804:BUSG135-MON; -.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    273       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_0000197982.
SQ   SEQUENCE   273 AA;  32424 MW;  0A3932B6C04AF711 CRC64;
     MSIYFISDIH GCYKEFKLLL KKSFFNDKKD FLWIAGDLVS RGPDSLKVIR YLYSLRKRIK
     IILGNHDLNL IAVYSGVKEN KKENYFDEFL SAKDNLQLIN WLRCQSILKI DEERKIIMSH
     AGISPKWDID TAKKYALEIE KCLSGKNYSS FLRSVFNNKI NYWNLNLNKL DRLRYSINVF
     TRMRYCYPDS RLNLICKKSP NLVKYPLIPW FKIPNKIPKE YSVFFGHWSS LIGTKVPQPF
     FPLDSGCCWG GKLTMFRWED KKYFFQSFQK NNS
//