Q8K9Z9 (APAH_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	BUsg_135

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_0000197982

Sequences

	Sequence		Length	Mass (Da)
	Q8K9Z9 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0A3932B6C04AF711	FASTA	273	32,424
	10 20 30 40 50 60 MSIYFISDIH GCYKEFKLLL KKSFFNDKKD FLWIAGDLVS RGPDSLKVIR YLYSLRKRIK 70 80 90 100 110 120 IILGNHDLNL IAVYSGVKEN KKENYFDEFL SAKDNLQLIN WLRCQSILKI DEERKIIMSH 130 140 150 160 170 180 AGISPKWDID TAKKYALEIE KCLSGKNYSS FLRSVFNNKI NYWNLNLNKL DRLRYSINVF 190 200 210 220 230 240 TRMRYCYPDS RLNLICKKSP NLVKYPLIPW FKIPNKIPKE YSVFFGHWSS LIGTKVPQPF 250 260 270 FPLDSGCCWG GKLTMFRWED KKYFFQSFQK NNS

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67703.1.
RefSeq	NP_660492.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9Z9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000093; EBBUCP00000000093; EBBUCG00000000093.
GeneID	1005952.
GenomeReviews	Gene locus BUsg_135 in contig AE013218_GR.
KEGG	bas:BUsg135.
PATRIC	21247051. VBIBucAph100086_0139.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008157.
HOGENOM	HBG724457.
OMA	LVFGHWA.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG135-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_BUCAP

Accession

Primary (citable) accession number: Q8K9Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program