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Q8K9Z3

- LSPA_BUCAP

UniProt

Q8K9Z3 - LSPA_BUCAP

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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111UniRule annotation
Active sitei138 – 1381UniRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-151-MONOMER.
UniPathwayiUPA00665.

Protein family/group databases

MEROPSiA08.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:BUsg_141
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 5820HelicalUniRule annotationAdd
BLAST
Transmembranei68 – 8518HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11923HelicalUniRule annotationAdd
BLAST
Transmembranei129 – 14921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Lipoprotein signal peptidasePRO_0000178772Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg141.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0597.
KOiK03101.
OMAiDFASKQW.
OrthoDBiEOG6PGKBM.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9Z3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRKYYWIYI NIIFFIITVD FYSKKWILNH LNIYEKQKVF FILNLFHVHN
60 70 80 90 100
FGAAFSILSD QNGWQKYFLL IFSIIIILAI IKIMIKFKKK DKNKILSYSL
110 120 130 140 150
ILAGAIGNLI DRINYGFVID FIDLHFKSWH FATFNIADFS IFIGMIMIIK

KNYYNS
Length:156
Mass (Da):18,748
Last modified:October 1, 2002 - v1
Checksum:iE5A3D4682F286DC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67709.1.
RefSeqiNP_660498.1. NC_004061.1.
WP_011053676.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67709; AAM67709; BUsg_141.
GeneIDi1005958.
KEGGibas:BUsg141.
PATRICi21247063. VBIBucAph100086_0145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67709.1 .
RefSeqi NP_660498.1. NC_004061.1.
WP_011053676.1. NC_004061.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg141.

Protein family/group databases

MEROPSi A08.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67709 ; AAM67709 ; BUsg_141 .
GeneIDi 1005958.
KEGGi bas:BUsg141.
PATRICi 21247063. VBIBucAph100086_0145.

Phylogenomic databases

eggNOGi COG0597.
KOi K03101.
OMAi DFASKQW.
OrthoDBi EOG6PGKBM.

Enzyme and pathway databases

UniPathwayi UPA00665 .
BioCyci BAPH198804:GHMG-151-MONOMER.

Family and domain databases

HAMAPi MF_00161. LspA.
InterProi IPR001872. Peptidase_A8.
[Graphical view ]
Pfami PF01252. Peptidase_A8. 1 hit.
[Graphical view ]
PRINTSi PR00781. LIPOSIGPTASE.
TIGRFAMsi TIGR00077. lspA. 1 hit.
PROSITEi PS00855. SPASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiLSPA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3