ID   RIBF_BUCAP              Reviewed;         312 AA.
AC   Q8K9Z1;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=Riboflavin biosynthesis protein ribF;
DE   Includes:
DE     RecName: Full=Riboflavin kinase;
DE              EC=2.7.1.26;
DE     AltName: Full=Flavokinase;
DE   Includes:
DE     RecName: Full=FMN adenylyltransferase;
DE              EC=2.7.7.2;
DE     AltName: Full=FAD pyrophosphorylase;
DE     AltName: Full=FAD synthetase;
GN   Name=ribF; OrderedLocusNames=BUsg_143;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + riboflavin = ADP + FMN.
CC   -!- CATALYTIC ACTIVITY: ATP + FMN = diphosphate + FAD.
CC   -!- PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN:
CC       step 1/1.
CC   -!- PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from
CC       riboflavin (ATP route): step 1/1.
CC   -!- SIMILARITY: Belongs to the ribF family.
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DR   EMBL; AE013218; AAM67711.1; -; Genomic_DNA.
DR   RefSeq; NP_660500.1; -.
DR   HSSP; O74866; 1N08.
DR   GeneID; 1005960; -.
DR   GenomeReviews; AE013218_GR; BUsg_143.
DR   KEGG; bas:BUsg143; -.
DR   HOGENOM; Q8K9Z1; -.
DR   OMA; Q8K9Z1; GVHLGHR.
DR   BioCyc; BAPH198804:BUSG143-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003919; F:FMN adenylyltransferase activity; IEA:EC.
DR   GO; GO:0008531; F:riboflavin kinase activity; IEA:EC.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR   InterPro; IPR015864; FAD_synthase.
DR   InterPro; IPR015865; Riboflavin_kinase.
DR   InterPro; IPR002606; Riboflavin_kinase/FAD_synth.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Gene3D; G3DSA:2.40.30.30; Riboflavin_kinase; 1.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   PANTHER; PTHR22749; Riboflavin_kinase; 1.
DR   Pfam; PF06574; FAD_syn; 1.
DR   Pfam; PF01687; Flavokinase; 1.
DR   PIRSF; PIRSF004491; FAD_Synth; 1.
DR   ProDom; PD003662; FAD_Synth; 1.
DR   TIGRFAMs; TIGR00083; ribF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; FAD; FMN; Multifunctional enzyme;
KW   Nucleotide-binding; Nucleotidyltransferase; Transferase.
FT   CHAIN         1    312       Riboflavin biosynthesis protein ribF.
FT                                /FTId=PRO_0000194135.
SQ   SEQUENCE   312 AA;  36139 MW;  AEC2E18F28082DF4 CRC64;
     MKLIRGIHNL KKINSNSAVS IGNFDGVHLG HQKLLSNLYK IGKKNNILTV LILFEPQPLE
     FLNNKNSPKR LTTIQNKIKY IQSWKIDIIL CIKFNESFSS LSAEKFIKNI LITKLNIKFI
     IIGDDFRFGS KRNGNISLLK EIGYQYNFKV IEISSLLYKN KIKISSTNIR KCLLENKIEL
     ARKLLGRPFS ISGRVIHGNK IGRKLGYPTA NISLRKNIPL NNGVYAVKIS CFFNKKFVGI
     CNIGIKPSYF SSKKHRLLEV HLFNFNLNLY EEKIEVFLYK KIRNECFFSS KNKLKEQISK
     DIEIVKKYFN LI
//