ID   NUOA_BUCAP              Reviewed;         126 AA.
AC   Q8K9Y7;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=NADH-quinone oxidoreductase subunit A;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit A;
DE   AltName: Full=NDH-1 subunit A;
DE   AltName: Full=NUO1;
GN   Name=nuoA; OrderedLocusNames=BUsg_147;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be ubiquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits
CC       nuoA, H, J, K, L, M, N constitute the membrane sector of the
CC       complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE013218; AAM67715.1; -; Genomic_DNA.
DR   RefSeq; NP_660504.1; -.
DR   GeneID; 1005964; -.
DR   GenomeReviews; AE013218_GR; BUsg_147.
DR   KEGG; bas:BUsg147; -.
DR   HOGENOM; Q8K9Y7; -.
DR   OMA; Q8K9Y7; KEIAYES.
DR   BioCyc; BAPH198804:BUSG147-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:HAMAP.
DR   GO; GO:0019684; P:photosynthesis, light reaction; IEA:HAMAP.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01394; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   PANTHER; PTHR11058; Oxidored_q4; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase;
KW   Quinone; Transmembrane; Transport; Ubiquinone.
FT   CHAIN         1    126       NADH-quinone oxidoreductase subunit A.
FT                                /FTId=PRO_0000117867.
FT   TRANSMEM     14     34       Potential.
FT   TRANSMEM     66     86       Potential.
FT   TRANSMEM     96    116       Potential.
SQ   SEQUENCE   126 AA;  14783 MW;  013593C0DA118096 CRC64;
     MLKNTLDMTE YLSFLYFIFF SLFFCCFMLF TSWFLGGRSL SRYKNTPFES GVVSVGNTHL
     HFSVKFYLIA IFFVIFDVEA LYLYAWSVSI VESGWIGFVE ATIFILFLLL SLFYLVRIKA
     LNWVTS
//