Reviewed, UniProtKB/Swiss-Prot Q8K9Y5 (NUOCD_BUCAP)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C/D
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C/D
    NDH-1 subunit C/D

Gene names

Name:	nuoC
Synonyms:	nuoCD, nuoD
Ordered Locus Names:	BUsg_149

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01359
Subunit structure	NDH-1 is composed of 13 different subunits. Subunits nuoB, CD, E, F, and G constitute the peripheral sector of the complex By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	In the N-terminal section; belongs to the complex I 30 kDa subunit family. In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	NADH-quinone oxidoreductase subunit C/D HAMAP MF_01359		PRO_0000118682
Regions
	Region	1 – 187	187	NADH dehydrogenase I subunit C By similarity
	Region	211 – 597	387	NADH dehydrogenase I subunit D By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K9Y5-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CC39F0373D2F387A	FASTA	597	69,343
	10 20 30 40 50 60 MIDENKKKNT NLNKNEYEEK SILKDLFHFF GKDFCVVQDT CIDFPVIWIN KSLLLKVGKF 70 80 90 100 110 120 LSSSPKPYNM LFDLHGVDER FRLNRLNLPE ADFSIFYHLI SIERNSDILI KVPLLKDDLN 130 140 150 160 170 180 VSTFISLFPN ANWYERETWE MFGIIFDQHP NLTHIIMPNE WKGFPLRKDY PARATEHESF 190 200 210 220 230 240 FLDEQKEDLE MENLRFKPEL WGMKRKNDNV DFMFLNLGPN HPSAHGAFRI VLQLDGENIV 250 260 270 280 290 300 DCVPDIGYHH RGAEKMAERQ SWHSYIPYTD RIEYLGGCVN EMPYVLAVEK LANISVPEKV 310 320 330 340 350 360 EVIRVMLSEL FRINSHLLYI STFIQDVGCM TPVFLAFTDR QKIYDLIEAI TGARMHPAWF 370 380 390 400 410 420 RIGGVAHDLP KGWNVLLKEF LEWMPKRLKY YVQLALENPI LIRRSKGIAQ YNQKEALQWG 430 440 450 460 470 480 VTGSGLRSTG LDLDVRKWRP YSGYQNYTFE IPIGQGISDC YSRVIIKVEE IYQSLSILKQ 490 500 510 520 530 540 CLKNMPEGPF KSDHPLTTPP PKERVLKDID TMITHFLQVS WGPVIPANES FQMIEATKGI 550 560 570 580 590 NSYYLISDGG TMSYRTRIRT PSFPHLQQIP SVIRGSLISD LIVYLGSIDF VMSDVDR

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67717.1.
RefSeq	NP_660506.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1005966.
GenomeReviews	Gene locus BUsg_149 in contig AE013218_GR.
KEGG	bas:BUsg149.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K9Y5.
OMA	Q8K9Y5. PPTWEGH.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG149-MON.
Family and domain databases
HAMAP	MF_01359. [Tree]
InterPro	IPR010219. NADH_DH_1_dsu. IPR010218. NADH_DH_csu. IPR001135. NADH_Q_OxRdtase_suD. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. IPR014029. NADH_UbQ_OxRdtase_su-49kDa_CS. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. PF00346. Complex1_49kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit. TIGR01962. NuoD. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. False negative. PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOCD_BUCAP

Accession

Primary (citable) accession number: Q8K9Y5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)