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Q8K9Y3

- NUOF_BUCAP

UniProt

Q8K9Y3 - NUOF_BUCAP

Protein

NADH-quinone oxidoreductase subunit F

Gene

nuoF

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.

    Cofactori

    Binds 1 4Fe-4S cluster.Curated
    FMN.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi352 – 3521Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi355 – 3551Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi358 – 3581Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi399 – 3991Iron-sulfur (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 7010NADBy similarity
    Nucleotide bindingi174 – 22148FMNBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. FMN binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. NAD binding Source: InterPro
    5. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    6. quinone binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-161-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit F (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit F
    NDH-1 subunit F
    Gene namesi
    Name:nuoF
    Ordered Locus Names:BUsg_151
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447NADH-quinone oxidoreductase subunit FPRO_0000118572Add
    BLAST

    Keywords - PTMi

    Quinone

    Proteomic databases

    PRIDEiQ8K9Y3.

    Interactioni

    Subunit structurei

    Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9Y3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 51 kDa subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1894.
    KOiK00335.
    OMAiHEIGMVP.
    OrthoDBiEOG6W9XGK.

    Family and domain databases

    InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
    IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
    IPR011537. NADH-UbQ_OxRdtase_suF.
    IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
    IPR019554. Soluble_ligand-bd.
    [Graphical view]
    PfamiPF01512. Complex1_51K. 1 hit.
    PF10589. NADH_4Fe-4S. 1 hit.
    PF10531. SLBB. 1 hit.
    [Graphical view]
    SMARTiSM00928. NADH_4Fe-4S. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
    PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
    PS00645. COMPLEX1_51K_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNIIPTEET HPLTWRLRND RETVWIEEYC KKNGYFSLKK ALKTMCPEDV    50
    VHLIKESGLK GRGGAGFSTG LKWSLMSKDN SSKIRYLLCN ADEMEPGTYK 100
    DRFLMENIPH QLIEGMLLSA FALNVSRGYI FLRGEYIKAE YILKKSIQEA 150
    INFGFIGSNI LNSGFNFELF LHTGAGRYIC GEETALINSL EGRRANPRAK 200
    PPFPAVFGLW GKPTCVNNVE TLSNVPSIVL HGVNWYKKLS KSTDTTGTKL 250
    MGFSGKVNNP GVWELPFGTT AREILEDYAR GMKSGLFLKS WQPGGAGTDF 300
    LIEKHLDLPM DFTSIAKAGS RLGTAIAMAV DNKTNMISLV CNIEKFFSRE 350
    SCGLCTPCRE GLPWIVKILE SLEKKEGHKN DVKNLERLCL DLSPGKTFCA 400
    HAPGAVEPLQ SAIKYFRLEF EAGISIKKLK KCSNILGIQS NEFTSKV 447
    Length:447
    Mass (Da):49,865
    Last modified:October 1, 2002 - v1
    Checksum:iD11DE0940D67AB51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67719.1.
    RefSeqiNP_660508.1. NC_004061.1.
    WP_011053686.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67719; AAM67719; BUsg_151.
    GeneIDi1005968.
    KEGGibas:BUsg151.
    PATRICi21247083. VBIBucAph100086_0155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67719.1 .
    RefSeqi NP_660508.1. NC_004061.1.
    WP_011053686.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9Y3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg151.

    Proteomic databases

    PRIDEi Q8K9Y3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67719 ; AAM67719 ; BUsg_151 .
    GeneIDi 1005968.
    KEGGi bas:BUsg151.
    PATRICi 21247083. VBIBucAph100086_0155.

    Phylogenomic databases

    eggNOGi COG1894.
    KOi K00335.
    OMAi HEIGMVP.
    OrthoDBi EOG6W9XGK.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-161-MONOMER.

    Family and domain databases

    InterProi IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
    IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
    IPR011537. NADH-UbQ_OxRdtase_suF.
    IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
    IPR019554. Soluble_ligand-bd.
    [Graphical view ]
    Pfami PF01512. Complex1_51K. 1 hit.
    PF10589. NADH_4Fe-4S. 1 hit.
    PF10531. SLBB. 1 hit.
    [Graphical view ]
    SMARTi SM00928. NADH_4Fe-4S. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01959. nuoF_fam. 1 hit.
    PROSITEi PS00644. COMPLEX1_51K_1. 1 hit.
    PS00645. COMPLEX1_51K_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiNUOF_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3