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Q8K9Y3

- NUOF_BUCAP

UniProt

Q8K9Y3 - NUOF_BUCAP

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Protein
NADH-quinone oxidoreductase subunit F
Gene
nuoF, BUsg_151
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activityi

NADH + quinone = NAD+ + quinol.

Cofactori

Binds 1 4Fe-4S cluster Inferred.
FMN Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi352 – 3521Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi355 – 3551Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi358 – 3581Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi399 – 3991Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 7010NAD By similarity
Nucleotide bindingi174 – 22148FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. FMN binding Source: InterPro
  3. NAD binding Source: InterPro
  4. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-161-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit F (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit F
NDH-1 subunit F
Gene namesi
Name:nuoF
Ordered Locus Names:BUsg_151
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447NADH-quinone oxidoreductase subunit F
PRO_0000118572Add
BLAST

Keywords - PTMi

Quinone

Proteomic databases

PRIDEiQ8K9Y3.

Interactioni

Subunit structurei

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg151.

Structurei

3D structure databases

ProteinModelPortaliQ8K9Y3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1894.
KOiK00335.
OMAiHEIGMVP.
OrthoDBiEOG6W9XGK.

Family and domain databases

InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamiPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTiSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9Y3-1 [UniParc]FASTAAdd to Basket

« Hide

MNNIIPTEET HPLTWRLRND RETVWIEEYC KKNGYFSLKK ALKTMCPEDV    50
VHLIKESGLK GRGGAGFSTG LKWSLMSKDN SSKIRYLLCN ADEMEPGTYK 100
DRFLMENIPH QLIEGMLLSA FALNVSRGYI FLRGEYIKAE YILKKSIQEA 150
INFGFIGSNI LNSGFNFELF LHTGAGRYIC GEETALINSL EGRRANPRAK 200
PPFPAVFGLW GKPTCVNNVE TLSNVPSIVL HGVNWYKKLS KSTDTTGTKL 250
MGFSGKVNNP GVWELPFGTT AREILEDYAR GMKSGLFLKS WQPGGAGTDF 300
LIEKHLDLPM DFTSIAKAGS RLGTAIAMAV DNKTNMISLV CNIEKFFSRE 350
SCGLCTPCRE GLPWIVKILE SLEKKEGHKN DVKNLERLCL DLSPGKTFCA 400
HAPGAVEPLQ SAIKYFRLEF EAGISIKKLK KCSNILGIQS NEFTSKV 447
Length:447
Mass (Da):49,865
Last modified:October 1, 2002 - v1
Checksum:iD11DE0940D67AB51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67719.1.
RefSeqiNP_660508.1. NC_004061.1.
WP_011053686.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67719; AAM67719; BUsg_151.
GeneIDi1005968.
KEGGibas:BUsg151.
PATRICi21247083. VBIBucAph100086_0155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67719.1 .
RefSeqi NP_660508.1. NC_004061.1.
WP_011053686.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9Y3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg151.

Proteomic databases

PRIDEi Q8K9Y3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67719 ; AAM67719 ; BUsg_151 .
GeneIDi 1005968.
KEGGi bas:BUsg151.
PATRICi 21247083. VBIBucAph100086_0155.

Phylogenomic databases

eggNOGi COG1894.
KOi K00335.
OMAi HEIGMVP.
OrthoDBi EOG6W9XGK.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-161-MONOMER.

Family and domain databases

InterProi IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view ]
Pfami PF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view ]
SMARTi SM00928. NADH_4Fe-4S. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01959. nuoF_fam. 1 hit.
PROSITEi PS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiNUOF_BUCAP
AccessioniPrimary (citable) accession number: Q8K9Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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