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Reviewed, UniProtKB/Swiss-Prot Q8K9X3 (FOLC_BUCAP)

Last modified June 16, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bifunctional protein folC
Including the following 2 domains:
    1- Recommended name:
            Folylpolyglutamate synthase
              EC=6.3.2.17
        Alternative name(s):
            Folylpoly-gamma-glutamate synthetase
              Short name=FPGS
            Tetrahydrofolylpolyglutamate synthase
              Short name=Tetrahydrofolate synthase
    2- Recommended name:
            Dihydrofolate synthase
              EC=6.3.2.12
Gene names
Name: folC
Ordered Locus Names: BUsg_161
OrganismBuchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]
Taxonomic identifier98794 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Conversion of folates to polyglutamate derivatives.

Catalytic activity

ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).

ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Bifunctional protein folC
PRO_0000168301

Regions

Nucleotide binding50 – 567ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K9X3-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6F644AFF9144AED4

FASTA41847,631
        10         20         30         40         50         60 
MHKKKYTFSM WMKYLEKFDK KDRKNLFELK LIAKKLGLLN LKSFFFTVGG TNGKGTTCAM 

        70         80         90        100        110        120 
LEKLLLDSGY QVGLYTSPHL INYSERIKVN GLYLSEKDHI FSFLIIDAEK GNVSLTYFEF 

       130        140        150        160        170        180 
ITLSALFLFS QYSLDIIILE VGLGGRLDAT NIIDSDLSVI TNIGIDHTSC LGTDRISIGR 

       190        200        210        220        230        240 
EKSGIFRKGK IAVIGEKNIP ISVDEIAKEK KTILKKIDVD WFWTRTKIDS WNFIHSNIEL 

       250        260        270        280        290        300 
YNLPVSRIPL SNTAIALASL FYSGLEVNLK KLKSSISKVQ LSGRFQTVFN SPRIILDVAH 

       310        320        330        340        350        360 
NVHAALYLSE KIDEIDTEGQ IYAVFGILKD KDVAGVVQVL QKKINYWYVV NLKTNRSASI 

       370        380        390        400        410 
NYLKKKLSLN NALFFNNINE SWQAIKKVIT KKDIILVFGS FFTVSEFMSI KDRRLTLY 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE013218 Genomic DNA. Translation: AAM67729.1.
RefSeqNP_660518.1.

3D structure databases

HSSPHSSP built from PDB template 1FGS based on UniProtKB P15925.
ModBaseSearch...

Genome annotation databases

GeneID1005359.
GenomeReviewsGene locus BUsg_161 in contig AE013218_GR.
KEGGbas:BUsg161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8K9X3.
OMAQ8K9X3. SIHPTEI.

Enzyme and pathway databases

BioCycBAPH198804:BUSG161-MON.

Family and domain databases

InterProIPR018109. Folylpolyglutamate_synth_CS.
IPR001645. Fpolygl_synthtse.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
PANTHERPTHR11136. Fpolygl_synthtse. 1 hit.
PfamPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
TIGRFAMsTIGR01499. folC. 1 hit.
PROSITEPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLC_BUCAP
AccessionPrimary (citable) accession number: Q8K9X3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents