Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K9X3

- FOLC_BUCAP

UniProt

Q8K9X3 - FOLC_BUCAP

Protein

Bifunctional protein FolC

Gene

folC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conversion of folates to polyglutamate derivatives.

    Catalytic activityi

    ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
    ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 567ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. dihydrofolate synthase activity Source: UniProtKB-EC
    3. tetrahydrofolylpolyglutamate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. one-carbon metabolic process Source: UniProtKB-KW
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Folate biosynthesis, One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-171-MONOMER.
    UniPathwayiUPA00077; UER00157.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein FolC
    Including the following 2 domains:
    Folylpolyglutamate synthase (EC:6.3.2.17)
    Alternative name(s):
    Folylpoly-gamma-glutamate synthetase
    Short name:
    FPGS
    Tetrahydrofolylpolyglutamate synthase
    Short name:
    Tetrahydrofolate synthase
    Dihydrofolate synthase (EC:6.3.2.12)
    Gene namesi
    Name:folC
    Ordered Locus Names:BUsg_161
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Bifunctional protein FolCPRO_0000168301Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9X3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the folylpolyglutamate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0285.
    KOiK11754.
    OMAiHRDVASA.
    OrthoDBiEOG6ZPSW2.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR001645. Folylpolyglutamate_synth.
    IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    [Graphical view]
    PANTHERiPTHR11136. PTHR11136. 1 hit.
    PfamiPF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001563. Folylpolyglu_synth. 1 hit.
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01499. folC. 1 hit.
    PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9X3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKKKYTFSM WMKYLEKFDK KDRKNLFELK LIAKKLGLLN LKSFFFTVGG    50
    TNGKGTTCAM LEKLLLDSGY QVGLYTSPHL INYSERIKVN GLYLSEKDHI 100
    FSFLIIDAEK GNVSLTYFEF ITLSALFLFS QYSLDIIILE VGLGGRLDAT 150
    NIIDSDLSVI TNIGIDHTSC LGTDRISIGR EKSGIFRKGK IAVIGEKNIP 200
    ISVDEIAKEK KTILKKIDVD WFWTRTKIDS WNFIHSNIEL YNLPVSRIPL 250
    SNTAIALASL FYSGLEVNLK KLKSSISKVQ LSGRFQTVFN SPRIILDVAH 300
    NVHAALYLSE KIDEIDTEGQ IYAVFGILKD KDVAGVVQVL QKKINYWYVV 350
    NLKTNRSASI NYLKKKLSLN NALFFNNINE SWQAIKKVIT KKDIILVFGS 400
    FFTVSEFMSI KDRRLTLY 418
    Length:418
    Mass (Da):47,631
    Last modified:October 1, 2002 - v1
    Checksum:i6F644AFF9144AED4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67729.1.
    RefSeqiNP_660518.1. NC_004061.1.
    WP_011053696.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67729; AAM67729; BUsg_161.
    GeneIDi1005359.
    KEGGibas:BUsg161.
    PATRICi21247103. VBIBucAph100086_0165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67729.1 .
    RefSeqi NP_660518.1. NC_004061.1.
    WP_011053696.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9X3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg161.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67729 ; AAM67729 ; BUsg_161 .
    GeneIDi 1005359.
    KEGGi bas:BUsg161.
    PATRICi 21247103. VBIBucAph100086_0165.

    Phylogenomic databases

    eggNOGi COG0285.
    KOi K11754.
    OMAi HRDVASA.
    OrthoDBi EOG6ZPSW2.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00157 .
    BioCyci BAPH198804:GHMG-171-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR001645. Folylpolyglutamate_synth.
    IPR018109. Folylpolyglutamate_synth_CS.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    [Graphical view ]
    PANTHERi PTHR11136. PTHR11136. 1 hit.
    Pfami PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001563. Folylpolyglu_synth. 1 hit.
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01499. folC. 1 hit.
    PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
    PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiFOLC_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3