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Protein

Bifunctional protein FolC

Gene

folC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Conversion of folates to polyglutamate derivatives.

Catalytic activityi

ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 567ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. dihydrofolate synthase activity Source: UniProtKB-EC
  3. tetrahydrofolylpolyglutamate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. one-carbon metabolic process Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Folate biosynthesis, One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-171-MONOMER.
UniPathwayiUPA00077; UER00157.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolC
Including the following 2 domains:
Folylpolyglutamate synthase (EC:6.3.2.17)
Alternative name(s):
Folylpoly-gamma-glutamate synthetase
Short name:
FPGS
Tetrahydrofolylpolyglutamate synthase
Short name:
Tetrahydrofolate synthase
Dihydrofolate synthase (EC:6.3.2.12)
Gene namesi
Name:folC
Ordered Locus Names:BUsg_161
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Bifunctional protein FolCPRO_0000168301Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg161.

Structurei

3D structure databases

ProteinModelPortaliQ8K9X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the folylpolyglutamate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0285.
KOiK11754.
OMAiFFEMTVG.
OrthoDBiEOG6ZPSW2.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR001645. Folylpolyglutamate_synth.
IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
[Graphical view]
PANTHERiPTHR11136. PTHR11136. 1 hit.
PfamiPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
PIRSFiPIRSF001563. Folylpolyglu_synth. 1 hit.
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01499. folC. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKKKYTFSM WMKYLEKFDK KDRKNLFELK LIAKKLGLLN LKSFFFTVGG
60 70 80 90 100
TNGKGTTCAM LEKLLLDSGY QVGLYTSPHL INYSERIKVN GLYLSEKDHI
110 120 130 140 150
FSFLIIDAEK GNVSLTYFEF ITLSALFLFS QYSLDIIILE VGLGGRLDAT
160 170 180 190 200
NIIDSDLSVI TNIGIDHTSC LGTDRISIGR EKSGIFRKGK IAVIGEKNIP
210 220 230 240 250
ISVDEIAKEK KTILKKIDVD WFWTRTKIDS WNFIHSNIEL YNLPVSRIPL
260 270 280 290 300
SNTAIALASL FYSGLEVNLK KLKSSISKVQ LSGRFQTVFN SPRIILDVAH
310 320 330 340 350
NVHAALYLSE KIDEIDTEGQ IYAVFGILKD KDVAGVVQVL QKKINYWYVV
360 370 380 390 400
NLKTNRSASI NYLKKKLSLN NALFFNNINE SWQAIKKVIT KKDIILVFGS
410
FFTVSEFMSI KDRRLTLY
Length:418
Mass (Da):47,631
Last modified:October 1, 2002 - v1
Checksum:i6F644AFF9144AED4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67729.1.
RefSeqiNP_660518.1. NC_004061.1.
WP_011053696.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67729; AAM67729; BUsg_161.
GeneIDi1005359.
KEGGibas:BUsg161.
PATRICi21247103. VBIBucAph100086_0165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67729.1.
RefSeqiNP_660518.1. NC_004061.1.
WP_011053696.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67729; AAM67729; BUsg_161.
GeneIDi1005359.
KEGGibas:BUsg161.
PATRICi21247103. VBIBucAph100086_0165.

Phylogenomic databases

eggNOGiCOG0285.
KOiK11754.
OMAiFFEMTVG.
OrthoDBiEOG6ZPSW2.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00157.
BioCyciBAPH198804:GHMG-171-MONOMER.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR001645. Folylpolyglutamate_synth.
IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
[Graphical view]
PANTHERiPTHR11136. PTHR11136. 1 hit.
PfamiPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
PIRSFiPIRSF001563. Folylpolyglu_synth. 1 hit.
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01499. folC. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiFOLC_BUCAP
AccessioniPrimary (citable) accession number: Q8K9X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.