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Q8K9X3

- FOLC_BUCAP

UniProt

Q8K9X3 - FOLC_BUCAP

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Protein

Bifunctional protein FolC

Gene

folC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Conversion of folates to polyglutamate derivatives.

Catalytic activityi

ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 567ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. dihydrofolate synthase activity Source: UniProtKB-EC
  3. tetrahydrofolylpolyglutamate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. one-carbon metabolic process Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Folate biosynthesis, One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-171-MONOMER.
UniPathwayiUPA00077; UER00157.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolC
Including the following 2 domains:
Folylpolyglutamate synthase (EC:6.3.2.17)
Alternative name(s):
Folylpoly-gamma-glutamate synthetase
Short name:
FPGS
Tetrahydrofolylpolyglutamate synthase
Short name:
Tetrahydrofolate synthase
Dihydrofolate synthase (EC:6.3.2.12)
Gene namesi
Name:folC
Ordered Locus Names:BUsg_161
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Bifunctional protein FolCPRO_0000168301Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg161.

Structurei

3D structure databases

ProteinModelPortaliQ8K9X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the folylpolyglutamate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0285.
KOiK11754.
OMAiHRDVASA.
OrthoDBiEOG6ZPSW2.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR001645. Folylpolyglutamate_synth.
IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
[Graphical view]
PANTHERiPTHR11136. PTHR11136. 1 hit.
PfamiPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
PIRSFiPIRSF001563. Folylpolyglu_synth. 1 hit.
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01499. folC. 1 hit.
PROSITEiPS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKKKYTFSM WMKYLEKFDK KDRKNLFELK LIAKKLGLLN LKSFFFTVGG
60 70 80 90 100
TNGKGTTCAM LEKLLLDSGY QVGLYTSPHL INYSERIKVN GLYLSEKDHI
110 120 130 140 150
FSFLIIDAEK GNVSLTYFEF ITLSALFLFS QYSLDIIILE VGLGGRLDAT
160 170 180 190 200
NIIDSDLSVI TNIGIDHTSC LGTDRISIGR EKSGIFRKGK IAVIGEKNIP
210 220 230 240 250
ISVDEIAKEK KTILKKIDVD WFWTRTKIDS WNFIHSNIEL YNLPVSRIPL
260 270 280 290 300
SNTAIALASL FYSGLEVNLK KLKSSISKVQ LSGRFQTVFN SPRIILDVAH
310 320 330 340 350
NVHAALYLSE KIDEIDTEGQ IYAVFGILKD KDVAGVVQVL QKKINYWYVV
360 370 380 390 400
NLKTNRSASI NYLKKKLSLN NALFFNNINE SWQAIKKVIT KKDIILVFGS
410
FFTVSEFMSI KDRRLTLY
Length:418
Mass (Da):47,631
Last modified:October 1, 2002 - v1
Checksum:i6F644AFF9144AED4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67729.1.
RefSeqiNP_660518.1. NC_004061.1.
WP_011053696.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67729; AAM67729; BUsg_161.
GeneIDi1005359.
KEGGibas:BUsg161.
PATRICi21247103. VBIBucAph100086_0165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67729.1 .
RefSeqi NP_660518.1. NC_004061.1.
WP_011053696.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9X3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67729 ; AAM67729 ; BUsg_161 .
GeneIDi 1005359.
KEGGi bas:BUsg161.
PATRICi 21247103. VBIBucAph100086_0165.

Phylogenomic databases

eggNOGi COG0285.
KOi K11754.
OMAi HRDVASA.
OrthoDBi EOG6ZPSW2.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00157 .
BioCyci BAPH198804:GHMG-171-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR001645. Folylpolyglutamate_synth.
IPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
[Graphical view ]
PANTHERi PTHR11136. PTHR11136. 1 hit.
Pfami PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF001563. Folylpolyglu_synth. 1 hit.
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01499. folC. 1 hit.
PROSITEi PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit.
PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiFOLC_BUCAP
AccessioniPrimary (citable) accession number: Q8K9X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3