Q8K9X2 (KPRS_BUCAP) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase Short name=RPPK EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthase Short name=P-Rib-PP synthase Short name=PRPP synthase | ||||||
| Gene names |
| ||||||
| Organism | Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 198804 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera |
Protein attributes
| Sequence length | 315 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B |
| Pathway | Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00583_B. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: InterPro ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 315 | 315 | Ribose-phosphate pyrophosphokinase HAMAP MF_00583_B | PRO_0000141119 | |||||
Regions | |||||||||
| Region | 213 – 226 | 14 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 129 | 1 | Magnesium Potential | ||||||
| Metal binding | 131 | 1 | Magnesium Potential | ||||||
| Metal binding | 140 | 1 | Magnesium Potential | ||||||
| Metal binding | 144 | 1 | Magnesium Potential | ||||||
Sequences
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References
| [1] | "50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE013218 Genomic DNA. Translation: AAM67730.1. |
| RefSeq | NP_660519.1. NC_004061.1. |
3D structure databases | |
| ProteinModelPortal | Q8K9X2. |
| SMR | Q8K9X2. Positions 3-312. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBUCT00000000335; EBBUCP00000000335; EBBUCG00000000335. |
| GeneID | 1005360. |
| GenomeReviews | Gene locus BUsg_163 in contig AE013218_GR. |
| KEGG | bas:BUsg163. |
| PATRIC | 21247107. VBIBucAph100086_0167. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000007916. |
| HOGENOM | HBG519284. |
| OMA | TDTIPLT. |
| ProtClustDB | PRK01259. |
Enzyme and pathway databases | |
| BioCyc | BAPH198804:BUSG163-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00583_B. RibP_PPkinase_B. [Tree] |
| InterPro | IPR000842. PRib_PP_synth_CS. IPR000836. PRibTrfase. IPR005946. Rib-P_diPkinase. [Graphical view] |
| KO | K00948. |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. RibP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPRS_BUCAP | ||||||||
| Accession | Primary (citable) accession number: Q8K9X2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Buchnera aphidicola (subsp. Schizaphis graminum) Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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