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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation

GO - Molecular functioni

  1. translation release factor activity, codon specific Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-174-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1UniRule annotation
Short name:
RF-1UniRule annotation
Gene namesi
Name:prfAUniRule annotation
Ordered Locus Names:BUsg_165
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Peptide chain release factor 1PRO_0000177647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351N5-methylglutamineUniRule annotation

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg165.

Structurei

3D structure databases

ProteinModelPortaliQ8K9X0.
SMRiQ8K9X0. Positions 8-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0216.
KOiK02835.
OMAiWKVEIVS.
OrthoDBiEOG6TN48J.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSIFNKLK SLRNRYEEIE IMLSQKDTIS NQEKFKNLSK EYLQISEIVK
60 70 80 90 100
NFIKWEKLET DIKNINLLFN DVEMHDIAQE ELFIVKKQKK KLEEKIKILL
110 120 130 140 150
LPVDPNDQHS CFIEIRAATG GDESSIFAGE LFRMYTRYAE NYMWKTEIMS
160 170 180 190 200
SSENERGGFK EIIAKVTGKG ACGRLKFESG GHRVQRVPET ESQGRIHTST
210 220 230 240 250
CTVAIMPVRP KTKKEEIKVS DLKIDTFRSS GAGGQHVNTT DSAIRITHIP
260 270 280 290 300
SGNVVECQDE RSQHKNKAKA LSILSARVYA DKLAKSQKEN SSMRRILLGT
310 320 330 340 350
GERSDRNRTY NFAQNRITDH RINLTIYKLN EVLQGKLDLL IDPIMQEYQA
360
DMLSSLSEFK L
Length:361
Mass (Da):41,459
Last modified:October 1, 2002 - v1
Checksum:i0C69E163BA05D21D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67732.1.
RefSeqiNP_660521.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67732; AAM67732; BUsg_165.
KEGGibas:BUsg165.
PATRICi21247111. VBIBucAph100086_0169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67732.1.
RefSeqiNP_660521.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9X0.
SMRiQ8K9X0. Positions 8-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67732; AAM67732; BUsg_165.
KEGGibas:BUsg165.
PATRICi21247111. VBIBucAph100086_0169.

Phylogenomic databases

eggNOGiCOG0216.
KOiK02835.
OMAiWKVEIVS.
OrthoDBiEOG6TN48J.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-174-MONOMER.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiRF1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.